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Analysis of the PcrA-RNA polymerase complex reveals a helicase interaction motif and a role for PcrA/UvrD helicase in the suppression of R-loops

The PcrA/UvrD helicase binds directly to RNA polymerase (RNAP) but the structural basis for this interaction and its functional significance have remained unclear. In this work, we used biochemical assays and hydrogen-deuterium exchange coupled to mass spectrometry to study the PcrA-RNAP complex. We...

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Detalles Bibliográficos
Autores principales:	Urrutia-Irazabal, Inigo, Ault, James R, Sobott, Frank, Savery, Nigel J, Dillingham, Mark S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Chromosomes and Gene Expression
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8318588/ https://www.ncbi.nlm.nih.gov/pubmed/34279225 http://dx.doi.org/10.7554/eLife.68829

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