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Structure and analysis of nanobody binding to the human ASIC1a ion channel

ASIC1a is a proton-gated sodium channel involved in modulation of pain, fear, addiction, and ischemia-induced neuronal injury. We report isolation and characterization of alpaca-derived nanobodies (Nbs) that specifically target human ASIC1a. Cryo-electron microscopy of the human ASIC1a channel at pH...

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Detalles Bibliográficos
Autores principales:	Wu, Yangyu, Chen, Zhuyuan, Sigworth, Fred J, Canessa, Cecilia M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Structural Biology and Molecular Biophysics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8318589/ https://www.ncbi.nlm.nih.gov/pubmed/34319232 http://dx.doi.org/10.7554/eLife.67115

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