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Atypical ductal hyperplasia of the breast mimics breast cancer presentation treated surgically: a case report and literature review

Atypical ductal hyperplasia (ADH) is considered a benign lesion with increased malignant potential. ADH represents ~3% of total benign breast biopsy results. A 60-year-old woman with no family history of breast cancer presented with multiple painless lumps in the right breast and palpable right axil...

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Autores principales: Alwagdani, Nawaf M, Alnefaie, Sahar M, Kurshid, Arif, Kewan, Hanady
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8318601/
https://www.ncbi.nlm.nih.gov/pubmed/34336186
http://dx.doi.org/10.1093/jscr/rjab325
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author Alwagdani, Nawaf M
Alnefaie, Sahar M
Kurshid, Arif
Kewan, Hanady
author_facet Alwagdani, Nawaf M
Alnefaie, Sahar M
Kurshid, Arif
Kewan, Hanady
author_sort Alwagdani, Nawaf M
collection PubMed
description Atypical ductal hyperplasia (ADH) is considered a benign lesion with increased malignant potential. ADH represents ~3% of total benign breast biopsy results. A 60-year-old woman with no family history of breast cancer presented with multiple painless lumps in the right breast and palpable right axillary lymph nodes. Ultrasonography and mammography showed typical features of breast cancer. However, core needle biopsy revealed ADH without infiltrating malignancy. Based on a multidisciplinary decision, a right simple mastectomy with sentinel lymph node biopsy was chosen as the best treatment plan. The postoperative histopathology report showed the spread of ductal carcinoma in situ (DCIS) in all quadrants without any evidence of invasive cancer. It is challenging to obtain an accurate diagnosis of clinically palpable and multicentric ADH or DCIS based on preoperative radiological and histological evaluation, especially when dissonance between these two evaluation modalities exists.
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spelling pubmed-83186012021-07-29 Atypical ductal hyperplasia of the breast mimics breast cancer presentation treated surgically: a case report and literature review Alwagdani, Nawaf M Alnefaie, Sahar M Kurshid, Arif Kewan, Hanady J Surg Case Rep Case Report Atypical ductal hyperplasia (ADH) is considered a benign lesion with increased malignant potential. ADH represents ~3% of total benign breast biopsy results. A 60-year-old woman with no family history of breast cancer presented with multiple painless lumps in the right breast and palpable right axillary lymph nodes. Ultrasonography and mammography showed typical features of breast cancer. However, core needle biopsy revealed ADH without infiltrating malignancy. Based on a multidisciplinary decision, a right simple mastectomy with sentinel lymph node biopsy was chosen as the best treatment plan. The postoperative histopathology report showed the spread of ductal carcinoma in situ (DCIS) in all quadrants without any evidence of invasive cancer. It is challenging to obtain an accurate diagnosis of clinically palpable and multicentric ADH or DCIS based on preoperative radiological and histological evaluation, especially when dissonance between these two evaluation modalities exists. Oxford University Press 2021-07-26 /pmc/articles/PMC8318601/ /pubmed/34336186 http://dx.doi.org/10.1093/jscr/rjab325 Text en Published by Oxford University Press and JSCR Publishing Ltd. All rights reserved. © The Author(s) 2021. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Case Report
Alwagdani, Nawaf M
Alnefaie, Sahar M
Kurshid, Arif
Kewan, Hanady
Atypical ductal hyperplasia of the breast mimics breast cancer presentation treated surgically: a case report and literature review
title Atypical ductal hyperplasia of the breast mimics breast cancer presentation treated surgically: a case report and literature review
title_full Atypical ductal hyperplasia of the breast mimics breast cancer presentation treated surgically: a case report and literature review
title_fullStr Atypical ductal hyperplasia of the breast mimics breast cancer presentation treated surgically: a case report and literature review
title_full_unstemmed Atypical ductal hyperplasia of the breast mimics breast cancer presentation treated surgically: a case report and literature review
title_short Atypical ductal hyperplasia of the breast mimics breast cancer presentation treated surgically: a case report and literature review
title_sort atypical ductal hyperplasia of the breast mimics breast cancer presentation treated surgically: a case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8318601/
https://www.ncbi.nlm.nih.gov/pubmed/34336186
http://dx.doi.org/10.1093/jscr/rjab325
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