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The effects of surface topography modification on hydrogel properties
Hydrogel has been an attractive biomaterial for tissue engineering, drug delivery, wound healing, and contact lens materials, due to its outstanding properties, including high water content, transparency, biocompatibility, tissue mechanical matching, and low toxicity. As hydrogel commonly possesses...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AIP Publishing LLC
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8318605/ https://www.ncbi.nlm.nih.gov/pubmed/34368603 http://dx.doi.org/10.1063/5.0046076 |
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author | Cui, Linan Yao, Yuan Yim, Evelyn K. F. |
author_facet | Cui, Linan Yao, Yuan Yim, Evelyn K. F. |
author_sort | Cui, Linan |
collection | PubMed |
description | Hydrogel has been an attractive biomaterial for tissue engineering, drug delivery, wound healing, and contact lens materials, due to its outstanding properties, including high water content, transparency, biocompatibility, tissue mechanical matching, and low toxicity. As hydrogel commonly possesses high surface hydrophilicity, chemical modifications have been applied to achieve the optimal surface properties to improve the performance of hydrogels for specific applications. Ideally, the effects of surface modifications would be stable, and the modification would not affect the inherent hydrogel properties. In recent years, a new type of surface modification has been discovered to be able to alter hydrogel properties by physically patterning the hydrogel surfaces with topographies. Such physical patterning methods can also affect hydrogel surface chemical properties, such as protein adsorption, microbial adhesion, and cell response. This review will first summarize the works on developing hydrogel surface patterning methods. The influence of surface topography on interfacial energy and the subsequent effects on protein adsorption, microbial, and cell interactions with patterned hydrogel, with specific examples in biomedical applications, will be discussed. Finally, current problems and future challenges on topographical modification of hydrogels will also be discussed. |
format | Online Article Text |
id | pubmed-8318605 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | AIP Publishing LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-83186052021-08-05 The effects of surface topography modification on hydrogel properties Cui, Linan Yao, Yuan Yim, Evelyn K. F. APL Bioeng Reviews Hydrogel has been an attractive biomaterial for tissue engineering, drug delivery, wound healing, and contact lens materials, due to its outstanding properties, including high water content, transparency, biocompatibility, tissue mechanical matching, and low toxicity. As hydrogel commonly possesses high surface hydrophilicity, chemical modifications have been applied to achieve the optimal surface properties to improve the performance of hydrogels for specific applications. Ideally, the effects of surface modifications would be stable, and the modification would not affect the inherent hydrogel properties. In recent years, a new type of surface modification has been discovered to be able to alter hydrogel properties by physically patterning the hydrogel surfaces with topographies. Such physical patterning methods can also affect hydrogel surface chemical properties, such as protein adsorption, microbial adhesion, and cell response. This review will first summarize the works on developing hydrogel surface patterning methods. The influence of surface topography on interfacial energy and the subsequent effects on protein adsorption, microbial, and cell interactions with patterned hydrogel, with specific examples in biomedical applications, will be discussed. Finally, current problems and future challenges on topographical modification of hydrogels will also be discussed. AIP Publishing LLC 2021-07-27 /pmc/articles/PMC8318605/ /pubmed/34368603 http://dx.doi.org/10.1063/5.0046076 Text en © 2021 Author(s). https://creativecommons.org/licenses/by/4.0/All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Reviews Cui, Linan Yao, Yuan Yim, Evelyn K. F. The effects of surface topography modification on hydrogel properties |
title | The effects of surface topography modification on hydrogel properties |
title_full | The effects of surface topography modification on hydrogel properties |
title_fullStr | The effects of surface topography modification on hydrogel properties |
title_full_unstemmed | The effects of surface topography modification on hydrogel properties |
title_short | The effects of surface topography modification on hydrogel properties |
title_sort | effects of surface topography modification on hydrogel properties |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8318605/ https://www.ncbi.nlm.nih.gov/pubmed/34368603 http://dx.doi.org/10.1063/5.0046076 |
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