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Transcranial sonography in differential diagnosis of Parkinson disease and other movement disorders

BACKGROUND: Reports evaluating the efficacy of transcranial sonography (TCS) for the differential diagnosis of Parkinson disease (PD) and other movement disorders in China are scarce. Therefore, this study aimed to assess the application of TCS for the differential diagnosis of PD, multiple system a...

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Autores principales: Wang, Li-Shu, Yu, Teng-Fei, Chai, Bin, He, Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8318650/
https://www.ncbi.nlm.nih.gov/pubmed/34238849
http://dx.doi.org/10.1097/CM9.0000000000001503
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author Wang, Li-Shu
Yu, Teng-Fei
Chai, Bin
He, Wen
author_facet Wang, Li-Shu
Yu, Teng-Fei
Chai, Bin
He, Wen
author_sort Wang, Li-Shu
collection PubMed
description BACKGROUND: Reports evaluating the efficacy of transcranial sonography (TCS) for the differential diagnosis of Parkinson disease (PD) and other movement disorders in China are scarce. Therefore, this study aimed to assess the application of TCS for the differential diagnosis of PD, multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and essential tremor (ET) in Chinese individuals. METHODS: From 2017 to 2019, 500 inpatients treated at the Department of Dyskinesia, Beijing Tiantan Hospital, Capital Medical University underwent routine transcranial ultrasound examination. The cross-sections at the midbrain and thalamus levels were scanned, and the incidence rates of substantia nigra (SN) positivity and the incidence rates of lenticular hyperechoic area were recorded. The echo of the SN was manually measured. RESULTS: Of the 500 patients, 125 were excluded due to poor signal in temporal window sound transmission. Among the 375 individuals with good temporal window sound transmission, 200 were diagnosed with PD, 90 with ET, 50 with MSA, and 35 with PSP. The incidence rates of SN positivity differed significantly among the four patient groups (χ(2) = 121.061, P < 0.001). Between-group comparisons were performed, and the PD group showed a higher SN positivity rate than the ET (χ(2) = 94.898, P < 0.017), MSA (χ(2) = 57.619, P < 0.017), and PSP (χ(2) = 37.687, P < 0.017) groups. SN positivity showed a good diagnostic value for differentiating PD from the other three movement diseases, collectively or individually. The incidences of lenticular hyperechoic area significantly differed among the four patient groups (χ(2) = 38.904, P < 0.001). Next, between-group comparisons were performed. The lenticular hyperechoic area was higher in the PD group than in the ET (χ(2) = 6.714, P < 0.017) and MSA (χ(2) = 18.680, P < 0.017) groups but lower than that in the PSP group (χ(2) = 0.679, P > 0.017). CONCLUSION: SN positivity could effectively differentiate PD from ET, PSP, and MSA in a Chinese population.
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spelling pubmed-83186502021-07-30 Transcranial sonography in differential diagnosis of Parkinson disease and other movement disorders Wang, Li-Shu Yu, Teng-Fei Chai, Bin He, Wen Chin Med J (Engl) Original Articles BACKGROUND: Reports evaluating the efficacy of transcranial sonography (TCS) for the differential diagnosis of Parkinson disease (PD) and other movement disorders in China are scarce. Therefore, this study aimed to assess the application of TCS for the differential diagnosis of PD, multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and essential tremor (ET) in Chinese individuals. METHODS: From 2017 to 2019, 500 inpatients treated at the Department of Dyskinesia, Beijing Tiantan Hospital, Capital Medical University underwent routine transcranial ultrasound examination. The cross-sections at the midbrain and thalamus levels were scanned, and the incidence rates of substantia nigra (SN) positivity and the incidence rates of lenticular hyperechoic area were recorded. The echo of the SN was manually measured. RESULTS: Of the 500 patients, 125 were excluded due to poor signal in temporal window sound transmission. Among the 375 individuals with good temporal window sound transmission, 200 were diagnosed with PD, 90 with ET, 50 with MSA, and 35 with PSP. The incidence rates of SN positivity differed significantly among the four patient groups (χ(2) = 121.061, P < 0.001). Between-group comparisons were performed, and the PD group showed a higher SN positivity rate than the ET (χ(2) = 94.898, P < 0.017), MSA (χ(2) = 57.619, P < 0.017), and PSP (χ(2) = 37.687, P < 0.017) groups. SN positivity showed a good diagnostic value for differentiating PD from the other three movement diseases, collectively or individually. The incidences of lenticular hyperechoic area significantly differed among the four patient groups (χ(2) = 38.904, P < 0.001). Next, between-group comparisons were performed. The lenticular hyperechoic area was higher in the PD group than in the ET (χ(2) = 6.714, P < 0.017) and MSA (χ(2) = 18.680, P < 0.017) groups but lower than that in the PSP group (χ(2) = 0.679, P > 0.017). CONCLUSION: SN positivity could effectively differentiate PD from ET, PSP, and MSA in a Chinese population. Lippincott Williams & Wilkins 2021-07-20 2021-07-07 /pmc/articles/PMC8318650/ /pubmed/34238849 http://dx.doi.org/10.1097/CM9.0000000000001503 Text en Copyright © 2021 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Original Articles
Wang, Li-Shu
Yu, Teng-Fei
Chai, Bin
He, Wen
Transcranial sonography in differential diagnosis of Parkinson disease and other movement disorders
title Transcranial sonography in differential diagnosis of Parkinson disease and other movement disorders
title_full Transcranial sonography in differential diagnosis of Parkinson disease and other movement disorders
title_fullStr Transcranial sonography in differential diagnosis of Parkinson disease and other movement disorders
title_full_unstemmed Transcranial sonography in differential diagnosis of Parkinson disease and other movement disorders
title_short Transcranial sonography in differential diagnosis of Parkinson disease and other movement disorders
title_sort transcranial sonography in differential diagnosis of parkinson disease and other movement disorders
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8318650/
https://www.ncbi.nlm.nih.gov/pubmed/34238849
http://dx.doi.org/10.1097/CM9.0000000000001503
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