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Antimicrobial Peptides: Novel Source and Biological Function With a Special Focus on Entomopathogenic Nematode/Bacterium Symbiotic Complex

The rapid emergence of multidrug resistant microorganisms has become one of the most critical threats to public health. A decrease in the effectiveness of available antibiotics has led to the failure of infection control, resulting in a high risk of death. Among several alternatives, antimicrobial p...

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Autores principales: De Mandal, Surajit, Panda, Amrita Kumari, Murugan, Chandran, Xu, Xiaoxia, Senthil Kumar, Nachimuthu, Jin, Fengliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8318700/
https://www.ncbi.nlm.nih.gov/pubmed/34335484
http://dx.doi.org/10.3389/fmicb.2021.555022
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author De Mandal, Surajit
Panda, Amrita Kumari
Murugan, Chandran
Xu, Xiaoxia
Senthil Kumar, Nachimuthu
Jin, Fengliang
author_facet De Mandal, Surajit
Panda, Amrita Kumari
Murugan, Chandran
Xu, Xiaoxia
Senthil Kumar, Nachimuthu
Jin, Fengliang
author_sort De Mandal, Surajit
collection PubMed
description The rapid emergence of multidrug resistant microorganisms has become one of the most critical threats to public health. A decrease in the effectiveness of available antibiotics has led to the failure of infection control, resulting in a high risk of death. Among several alternatives, antimicrobial peptides (AMPs) serve as potential alternatives to antibiotics to resolve the emergence and spread of multidrug-resistant pathogens. These small proteins exhibit potent antimicrobial activity and are also an essential component of the immune system. Although several AMPs have been reported and characterized, studies associated with their potential medical applications are limited. This review highlights the novel sources of AMPs with high antimicrobial activities, including the entomopathogenic nematode/bacterium (EPN/EPB) symbiotic complex. Additionally, the AMPs derived from insects, nematodes, and marine organisms and the design of peptidomimetic antimicrobial agents that can complement the defects of therapeutic peptides have been used as a template.
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spelling pubmed-83187002021-07-29 Antimicrobial Peptides: Novel Source and Biological Function With a Special Focus on Entomopathogenic Nematode/Bacterium Symbiotic Complex De Mandal, Surajit Panda, Amrita Kumari Murugan, Chandran Xu, Xiaoxia Senthil Kumar, Nachimuthu Jin, Fengliang Front Microbiol Microbiology The rapid emergence of multidrug resistant microorganisms has become one of the most critical threats to public health. A decrease in the effectiveness of available antibiotics has led to the failure of infection control, resulting in a high risk of death. Among several alternatives, antimicrobial peptides (AMPs) serve as potential alternatives to antibiotics to resolve the emergence and spread of multidrug-resistant pathogens. These small proteins exhibit potent antimicrobial activity and are also an essential component of the immune system. Although several AMPs have been reported and characterized, studies associated with their potential medical applications are limited. This review highlights the novel sources of AMPs with high antimicrobial activities, including the entomopathogenic nematode/bacterium (EPN/EPB) symbiotic complex. Additionally, the AMPs derived from insects, nematodes, and marine organisms and the design of peptidomimetic antimicrobial agents that can complement the defects of therapeutic peptides have been used as a template. Frontiers Media S.A. 2021-07-14 /pmc/articles/PMC8318700/ /pubmed/34335484 http://dx.doi.org/10.3389/fmicb.2021.555022 Text en Copyright © 2021 De Mandal, Panda, Murugan, Xu, Senthil Kumar and Jin. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
De Mandal, Surajit
Panda, Amrita Kumari
Murugan, Chandran
Xu, Xiaoxia
Senthil Kumar, Nachimuthu
Jin, Fengliang
Antimicrobial Peptides: Novel Source and Biological Function With a Special Focus on Entomopathogenic Nematode/Bacterium Symbiotic Complex
title Antimicrobial Peptides: Novel Source and Biological Function With a Special Focus on Entomopathogenic Nematode/Bacterium Symbiotic Complex
title_full Antimicrobial Peptides: Novel Source and Biological Function With a Special Focus on Entomopathogenic Nematode/Bacterium Symbiotic Complex
title_fullStr Antimicrobial Peptides: Novel Source and Biological Function With a Special Focus on Entomopathogenic Nematode/Bacterium Symbiotic Complex
title_full_unstemmed Antimicrobial Peptides: Novel Source and Biological Function With a Special Focus on Entomopathogenic Nematode/Bacterium Symbiotic Complex
title_short Antimicrobial Peptides: Novel Source and Biological Function With a Special Focus on Entomopathogenic Nematode/Bacterium Symbiotic Complex
title_sort antimicrobial peptides: novel source and biological function with a special focus on entomopathogenic nematode/bacterium symbiotic complex
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8318700/
https://www.ncbi.nlm.nih.gov/pubmed/34335484
http://dx.doi.org/10.3389/fmicb.2021.555022
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