Cargando…

The Relationship Between Vitamin D and Infections Including COVID-19: Any Hopes?

Vitamin D is proposed to have a potential role in the pathogenicity, clinical presentation, prognosis, complications, and treatment of several diseases. In addition to its well-known role in calcium metabolism, vitamin D regulates both innate and adaptive immunity, and subsequently modulates the ant...

Descripción completa

Detalles Bibliográficos
Autores principales: Taha, Rbab, Abureesh, Shahd, Alghamdi, Shuruq, Hassan, Rola Y, Cheikh, Mohamed M, Bagabir, Rania A, Almoallim, Hani, Abdulkhaliq, Altaf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8318784/
https://www.ncbi.nlm.nih.gov/pubmed/34335050
http://dx.doi.org/10.2147/IJGM.S317421
_version_ 1783730315411324928
author Taha, Rbab
Abureesh, Shahd
Alghamdi, Shuruq
Hassan, Rola Y
Cheikh, Mohamed M
Bagabir, Rania A
Almoallim, Hani
Abdulkhaliq, Altaf
author_facet Taha, Rbab
Abureesh, Shahd
Alghamdi, Shuruq
Hassan, Rola Y
Cheikh, Mohamed M
Bagabir, Rania A
Almoallim, Hani
Abdulkhaliq, Altaf
author_sort Taha, Rbab
collection PubMed
description Vitamin D is proposed to have a potential role in the pathogenicity, clinical presentation, prognosis, complications, and treatment of several diseases. In addition to its well-known role in calcium metabolism, vitamin D regulates both innate and adaptive immunity, and subsequently modulates the antiviral and antibacterial inflammatory immune responses. In view of the emerging coronavirus disease 2019 (COVID-19) pandemic, searching for potential therapeutic and protective strategies is of urgent interest, and vitamin D is one of the promising agents in this field. In this review, we present data from literature that supports the promising role of vitamin D in treatment and/or prevention of several infections including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This review summarizes vitamin D metabolism and its role in inflammation, thrombosis and immune regulation. It also reviews, in short, the role of vitamin D and the impact of its deficiency in several infections namely tuberculosis, influenza, human immunodeficiency virus (HIV), and SARS-CoV-2. Considering the roles of vitamin D on immune modulation, controlling of thrombosis, and attacking several microorganisms, the current review will elaborate on the association between these salient roles of vitamin D and the pathogenicity of various infectious agents including COVID-19. Consequently, the comprehensive finding of the current review shows a possible significant impact of vitamin D supplement as a hope in preventing, treating, and/or improving the progression of certain infections, specifically during the worldwide attempts to fight against the COVID-19 pandemic and minimize the severity of health complications encountered accordingly. In addition, avoiding a status of vitamin D deficiency to obtain its positive effects on the immune system and its protective mechanism during infections will be a general benefit overall.
format Online
Article
Text
id pubmed-8318784
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Dove
record_format MEDLINE/PubMed
spelling pubmed-83187842021-07-30 The Relationship Between Vitamin D and Infections Including COVID-19: Any Hopes? Taha, Rbab Abureesh, Shahd Alghamdi, Shuruq Hassan, Rola Y Cheikh, Mohamed M Bagabir, Rania A Almoallim, Hani Abdulkhaliq, Altaf Int J Gen Med Review Vitamin D is proposed to have a potential role in the pathogenicity, clinical presentation, prognosis, complications, and treatment of several diseases. In addition to its well-known role in calcium metabolism, vitamin D regulates both innate and adaptive immunity, and subsequently modulates the antiviral and antibacterial inflammatory immune responses. In view of the emerging coronavirus disease 2019 (COVID-19) pandemic, searching for potential therapeutic and protective strategies is of urgent interest, and vitamin D is one of the promising agents in this field. In this review, we present data from literature that supports the promising role of vitamin D in treatment and/or prevention of several infections including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This review summarizes vitamin D metabolism and its role in inflammation, thrombosis and immune regulation. It also reviews, in short, the role of vitamin D and the impact of its deficiency in several infections namely tuberculosis, influenza, human immunodeficiency virus (HIV), and SARS-CoV-2. Considering the roles of vitamin D on immune modulation, controlling of thrombosis, and attacking several microorganisms, the current review will elaborate on the association between these salient roles of vitamin D and the pathogenicity of various infectious agents including COVID-19. Consequently, the comprehensive finding of the current review shows a possible significant impact of vitamin D supplement as a hope in preventing, treating, and/or improving the progression of certain infections, specifically during the worldwide attempts to fight against the COVID-19 pandemic and minimize the severity of health complications encountered accordingly. In addition, avoiding a status of vitamin D deficiency to obtain its positive effects on the immune system and its protective mechanism during infections will be a general benefit overall. Dove 2021-07-24 /pmc/articles/PMC8318784/ /pubmed/34335050 http://dx.doi.org/10.2147/IJGM.S317421 Text en © 2021 Taha et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Taha, Rbab
Abureesh, Shahd
Alghamdi, Shuruq
Hassan, Rola Y
Cheikh, Mohamed M
Bagabir, Rania A
Almoallim, Hani
Abdulkhaliq, Altaf
The Relationship Between Vitamin D and Infections Including COVID-19: Any Hopes?
title The Relationship Between Vitamin D and Infections Including COVID-19: Any Hopes?
title_full The Relationship Between Vitamin D and Infections Including COVID-19: Any Hopes?
title_fullStr The Relationship Between Vitamin D and Infections Including COVID-19: Any Hopes?
title_full_unstemmed The Relationship Between Vitamin D and Infections Including COVID-19: Any Hopes?
title_short The Relationship Between Vitamin D and Infections Including COVID-19: Any Hopes?
title_sort relationship between vitamin d and infections including covid-19: any hopes?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8318784/
https://www.ncbi.nlm.nih.gov/pubmed/34335050
http://dx.doi.org/10.2147/IJGM.S317421
work_keys_str_mv AT taharbab therelationshipbetweenvitamindandinfectionsincludingcovid19anyhopes
AT abureeshshahd therelationshipbetweenvitamindandinfectionsincludingcovid19anyhopes
AT alghamdishuruq therelationshipbetweenvitamindandinfectionsincludingcovid19anyhopes
AT hassanrolay therelationshipbetweenvitamindandinfectionsincludingcovid19anyhopes
AT cheikhmohamedm therelationshipbetweenvitamindandinfectionsincludingcovid19anyhopes
AT bagabirraniaa therelationshipbetweenvitamindandinfectionsincludingcovid19anyhopes
AT almoallimhani therelationshipbetweenvitamindandinfectionsincludingcovid19anyhopes
AT abdulkhaliqaltaf therelationshipbetweenvitamindandinfectionsincludingcovid19anyhopes
AT taharbab relationshipbetweenvitamindandinfectionsincludingcovid19anyhopes
AT abureeshshahd relationshipbetweenvitamindandinfectionsincludingcovid19anyhopes
AT alghamdishuruq relationshipbetweenvitamindandinfectionsincludingcovid19anyhopes
AT hassanrolay relationshipbetweenvitamindandinfectionsincludingcovid19anyhopes
AT cheikhmohamedm relationshipbetweenvitamindandinfectionsincludingcovid19anyhopes
AT bagabirraniaa relationshipbetweenvitamindandinfectionsincludingcovid19anyhopes
AT almoallimhani relationshipbetweenvitamindandinfectionsincludingcovid19anyhopes
AT abdulkhaliqaltaf relationshipbetweenvitamindandinfectionsincludingcovid19anyhopes