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Multifocal Langerhans cell histiocytosis in a child
Langerhans Cell Histiocytosis (LCH) is a rare disorder sometimes called the disorder of the “monocyte-macrophage system”. This condition is characterized by the proliferation of abnormal Langerhans cells within different tissues. Skin rash is the typical early feature, but bony involvement is the se...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8318828/ https://www.ncbi.nlm.nih.gov/pubmed/34336078 http://dx.doi.org/10.1016/j.radcr.2021.06.052 |
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author | Musa, Juna Siddik, Abu Bakar Ahmetgjekaj, Ilir Rahman, Masum Guy, Ali Rahman, Abdur Ikram, Samar Kola, Erisa Vokshi, Valon Ahsan, Eram Saliaj, Kristi Hyseni, Fjolla |
author_facet | Musa, Juna Siddik, Abu Bakar Ahmetgjekaj, Ilir Rahman, Masum Guy, Ali Rahman, Abdur Ikram, Samar Kola, Erisa Vokshi, Valon Ahsan, Eram Saliaj, Kristi Hyseni, Fjolla |
author_sort | Musa, Juna |
collection | PubMed |
description | Langerhans Cell Histiocytosis (LCH) is a rare disorder sometimes called the disorder of the “monocyte-macrophage system”. This condition is characterized by the proliferation of abnormal Langerhans cells within different tissues. Skin rash is the typical early feature, but bony involvement is the second most common presentation. The most common complications are musculoskeletal disabilities, hearing problems, skin scarring, neuropsychiatric defects and most importantly, progression to secondary malignancies like leukemia. Early recognition and treatment can reduce morbidity and mortality. Herein, we report a case of a 10-year-old male presenting with a tender, palpable mass in the lower limb. On initial imaging, a lesion involving the diaphysis of the fibula was observed, raising concerns of Ewing sarcoma. Biopsy was planned along with whole-body MRI, revealing multifocal single system Langerhans cell histiocytosis. Given the rarity of fibular involvement in LCH, distinguishing between LCH and common malignancies within this age-group can be challenging. Through this case report, we hope to emphasize the importance of considering LCH in the differential diagnosis to ensure a timely diagnosis, fitting treatment and improvement in prognosis of the condition. |
format | Online Article Text |
id | pubmed-8318828 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-83188282021-07-31 Multifocal Langerhans cell histiocytosis in a child Musa, Juna Siddik, Abu Bakar Ahmetgjekaj, Ilir Rahman, Masum Guy, Ali Rahman, Abdur Ikram, Samar Kola, Erisa Vokshi, Valon Ahsan, Eram Saliaj, Kristi Hyseni, Fjolla Radiol Case Rep Case Report Langerhans Cell Histiocytosis (LCH) is a rare disorder sometimes called the disorder of the “monocyte-macrophage system”. This condition is characterized by the proliferation of abnormal Langerhans cells within different tissues. Skin rash is the typical early feature, but bony involvement is the second most common presentation. The most common complications are musculoskeletal disabilities, hearing problems, skin scarring, neuropsychiatric defects and most importantly, progression to secondary malignancies like leukemia. Early recognition and treatment can reduce morbidity and mortality. Herein, we report a case of a 10-year-old male presenting with a tender, palpable mass in the lower limb. On initial imaging, a lesion involving the diaphysis of the fibula was observed, raising concerns of Ewing sarcoma. Biopsy was planned along with whole-body MRI, revealing multifocal single system Langerhans cell histiocytosis. Given the rarity of fibular involvement in LCH, distinguishing between LCH and common malignancies within this age-group can be challenging. Through this case report, we hope to emphasize the importance of considering LCH in the differential diagnosis to ensure a timely diagnosis, fitting treatment and improvement in prognosis of the condition. Elsevier 2021-07-17 /pmc/articles/PMC8318828/ /pubmed/34336078 http://dx.doi.org/10.1016/j.radcr.2021.06.052 Text en © 2021 Published by Elsevier Inc. on behalf of University of Washington. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Musa, Juna Siddik, Abu Bakar Ahmetgjekaj, Ilir Rahman, Masum Guy, Ali Rahman, Abdur Ikram, Samar Kola, Erisa Vokshi, Valon Ahsan, Eram Saliaj, Kristi Hyseni, Fjolla Multifocal Langerhans cell histiocytosis in a child |
title | Multifocal Langerhans cell histiocytosis in a child |
title_full | Multifocal Langerhans cell histiocytosis in a child |
title_fullStr | Multifocal Langerhans cell histiocytosis in a child |
title_full_unstemmed | Multifocal Langerhans cell histiocytosis in a child |
title_short | Multifocal Langerhans cell histiocytosis in a child |
title_sort | multifocal langerhans cell histiocytosis in a child |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8318828/ https://www.ncbi.nlm.nih.gov/pubmed/34336078 http://dx.doi.org/10.1016/j.radcr.2021.06.052 |
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