Nuclear translocation promotes proteasomal degradation of human Rad17 protein through the N-terminal destruction boxes

The ATR pathway is one of the major DNA damage checkpoints, and Rad17 is a DNA-binding protein that is phosphorylated upon DNA damage by ATR kinase. Rad17 recruits the 9-1-1 complex that mediates the checkpoint activation, and proteasomal degradation of Rad17 is important for recovery from the ATR p...

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Detalles Bibliográficos
Autores principales: Fukumoto, Yasunori, Ikeuchi, Masayoshi, Qu, Liang, Hoshino, Tyuji, Yamaguchi, Naoto, Nakayama, Yuji, Ogra, Yasumitsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8318897/
https://www.ncbi.nlm.nih.gov/pubmed/34174284
http://dx.doi.org/10.1016/j.jbc.2021.100831

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