Cargando…

Direct interaction of DNA repair protein tyrosyl DNA phosphodiesterase 1 and the DNA ligase III catalytic domain is regulated by phosphorylation of its flexible N-terminus

Tyrosyl DNA phosphodiesterase 1 (TDP1) and DNA Ligase IIIα (LigIIIα) are key enzymes in single-strand break (SSB) repair. TDP1 removes 3′-tyrosine residues remaining after degradation of DNA topoisomerase (TOP) 1 cleavage complexes trapped by either DNA lesions or TOP1 inhibitors. It is not known ho...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rashid, Ishtiaque, Hammel, Michal, Sverzhinsky, Aleksandr, Tsai, Miaw-Sheue, Pascal, John M., Tainer, John A., Tomkinson, Alan E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8318918/ https://www.ncbi.nlm.nih.gov/pubmed/34181949 http://dx.doi.org/10.1016/j.jbc.2021.100921

Ejemplares similares

An atypical BRCT–BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase IIIα within a flexible DNA repair complex
por: Hammel, Michal, et al.
Publicado: (2020)

An Intrinsically Disordered APLF Links Ku, DNA-PKcs, and XRCC4-DNA Ligase IV in an Extended Flexible Non-homologous End Joining Complex
por: Hammel, Michal, et al.
Publicado: (2016)

New Deoxycholic Acid Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitors Also Inhibit Tyrosyl-DNA Phosphodiesterase 2
por: Salomatina, Oksana V., et al.
Publicado: (2021)

Mammalian Tyrosyl-DNA Phosphodiesterases in the Context of Mitochondrial DNA Repair
por: Huang, Shar-yin Naomi, et al.
Publicado: (2019)

The DNA binding and 3′-end preferential activity of human tyrosyl-DNA phosphodiesterase
por: Dexheimer, Thomas S., et al.
Publicado: (2010)

Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2
por: Hornyak, Peter, et al.
Publicado: (2016)

Tyrosyl–DNA phosphodiesterases: rescuing the genome from the risks of relaxation
por: Kawale, Ajinkya S, et al.
Publicado: (2018)

Inhibition of Tyrosyl-DNA Phosphodiesterase 1 by Lipophilic Pyrimidine Nucleosides
por: Zakharenko, Alexandra L., et al.
Publicado: (2020)

Phosphonic acid-containing inhibitors of tyrosyl-DNA phosphodiesterase 1
por: Zhao, Xue Zhi, et al.
Publicado: (2022)

Human Tyrosyl-DNA Phosphodiesterase 1 Possesses Transphosphooligonucleotidation Activity With Primary Alcohols
por: Dyrkheeva, Nadezhda, et al.
Publicado: (2020)

Structural basis for DNA 3′-end processing by human tyrosyl-DNA phosphodiesterase 1
por: Flett, Fiona J., et al.
Publicado: (2018)

Targeting Tyrosyl-DNA phosphodiesterase I to enhance toxicity of phosphodiester linked DNA-adducts
por: Brettrager, Evan J., et al.
Publicado: (2019)

Natural Products and Their Derivatives as Inhibitors of the DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1
por: Zakharenko, Alexandra L., et al.
Publicado: (2023)

Tyrosyl-DNA phosphodiesterase 1 initiates repair of apurinic/apyrimidinic sites
por: Lebedeva, Natalia A., et al.
Publicado: (2012)

Dysregulated human Tyrosyl-DNA phosphodiesterase I acts as cellular toxin
por: Cuya, Selma M., et al.
Publicado: (2016)

Tyrosyl-DNA phosphodiesterases are involved in mutagenic events at a ribonucleotide embedded into DNA in human cells
por: Takeishi, Ayuna, et al.
Publicado: (2020)

Human DNA ligase III bridges two DNA ends to promote specific intermolecular DNA end joining
por: Kukshal, Vandna, et al.
Publicado: (2015)

The First Berberine-Based Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), an Important DNA Repair Enzyme
por: Gladkova, Elizaveta D., et al.
Publicado: (2020)

Identification of multidentate tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors that simultaneously access the DNA, protein and catalytic-binding sites by oxime diversification
por: Zhao, Xue Zhi, et al.
Publicado: (2023)

Characterization of magnesium requirement of human 5'-tyrosyl DNA phosphodiesterase mediated reaction
por: Adhikari, Sanjay, et al.
Publicado: (2012)

Structure Modeling of Human Tyrosyl-DNA Phosphodiesterase 1 and Screening for Its Inhibitors
por: Gushchina, I.V., et al.
Publicado: (2017)

Novel Semisynthetic Derivatives of Bile Acids as Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibitors
por: Salomatina, Oksana V., et al.
Publicado: (2018)

Usnic Acid Derivatives Inhibit DNA Repair Enzymes Tyrosyl-DNA Phosphodiesterases 1 and 2 and Act as Potential Anticancer Agents
por: Zakharenko, Alexandra L., et al.
Publicado: (2023)

Small molecule microarray identifies inhibitors of tyrosyl-DNA phosphodiesterase 1 that simultaneously access the catalytic pocket and two substrate binding sites
por: Zhao, Xue Zhi, et al.
Publicado: (2021)

Mechanism of 5′ Topoisomerase II DNA adduct repair by mammalian Tyrosyl DNA phosphodiesterase 2 (Tdp2)
por: Schellenberg, Matthew J., et al.
Publicado: (2012)

Poly(ADP-ribose)polymerase 1 stimulates the AP-site cleavage activity of tyrosyl-DNA phosphodiesterase 1
por: Lebedeva, Natalia A., et al.
Publicado: (2015)

Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors
por: Walker, Sarah, et al.
Publicado: (2014)

New Hybrid Compounds Combining Fragments of Usnic Acid and Monoterpenoids for Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibition
por: Dyrkheeva, Nadezhda S., et al.
Publicado: (2021)

Tyrosyl-DNA Phosphodiesterase I N-Terminal Domain Modifications and Interactions Regulate Cellular Function
por: Brettrager, Evan J., et al.
Publicado: (2019)

Influence of Tyrosyl-DNA Phosphodiesterase 1 Inhibitor on the Proapoptotic and Genotoxic Effects of Anticancer Agent Topotecan
por: Chepanova, A. A., et al.
Publicado: (2023)

Structure–function studies of a plant tyrosyl-DNA phosphodiesterase provide novel insights into DNA repair mechanisms of Arabidopsis thaliana
por: Kim, Hoyeun, et al.
Publicado: (2012)

Repair of topoisomerase 1–induced DNA damage by tyrosyl-DNA phosphodiesterase 2 (TDP2) is dependent on its magnesium binding
por: Shimizu, Naoto, et al.
Publicado: (2023)

Does Tyrosyl DNA Phosphodiesterase-2 Play a Role in Hepatitis B Virus Genome Repair?
por: Cui, Xiuji, et al.
Publicado: (2015)

Tyrosyl-DNA Phosphodiesterase 1 and Topoisomerase I Activities as Predictive Indicators for Glioblastoma Susceptibility to Genotoxic Agents
por: Wang, Wenjie, et al.
Publicado: (2019)

N-terminal domain of tyrosyl-DNA phosphodiesterase I regulates topoisomerase I-induced toxicity in cells
por: Brettrager, Evan J., et al.
Publicado: (2023)

Apurinic/Apyrimidinic Endonuclease 1 and Tyrosyl-DNA Phosphodiesterase 1 Prevent Suicidal Covalent DNA-Protein Crosslink at Apurinic/Apyrimidinic Site
por: Lebedeva, Natalia A., et al.
Publicado: (2021)

Tyrosyl-DNA phosphodiesterase 1 (TDP1) and SPRTN protease repair histone 3 and topoisomerase 1 DNA–protein crosslinks in vivo
por: Anticevic, Ivan, et al.
Publicado: (2023)

The C-terminal domain of yeast PCNA is required for physical and functional interactions with Cdc9 DNA ligase
por: Vijayakumar, Sangeetha, et al.
Publicado: (2007)

Deficiency in 3′-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1)
por: Zhou, Tong, et al.
Publicado: (2005)

The Tyrosyl-DNA Phosphodiesterase 1β (Tdp1β) Gene Discloses an Early Response to Abiotic Stresses
por: Sabatini, Maria Elisa, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_gte7n6n8fcs24n2lqnppts02uk