Arresting metastasis within the microcirculation

The behaviour of circulating tumour cells in the microcirculation remains poorly understood. Growing evidence suggests that biomechanical adaptations and interactions with blood components, i.e. immune cells and platelets within capillary beds, may add more complexity to CTCs journey towards metasta...

Descripción completa

Detalles Bibliográficos
Autores principales: Varotsos Vrynas, Angelos, Perea Paizal, Julia, Bakal, Chris, Au, Sam H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2021
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8318963/
https://www.ncbi.nlm.nih.gov/pubmed/34241735
http://dx.doi.org/10.1007/s10585-021-10109-8
Descripción
Sumario:The behaviour of circulating tumour cells in the microcirculation remains poorly understood. Growing evidence suggests that biomechanical adaptations and interactions with blood components, i.e. immune cells and platelets within capillary beds, may add more complexity to CTCs journey towards metastasis. Revisiting how these mediators impact the ability of circulating tumour cells to survive and metastasise, will be vital to understand the role of microcirculation and advance our knowledge on metastasis.

Ejemplares similares