Arresting metastasis within the microcirculation

The behaviour of circulating tumour cells in the microcirculation remains poorly understood. Growing evidence suggests that biomechanical adaptations and interactions with blood components, i.e. immune cells and platelets within capillary beds, may add more complexity to CTCs journey towards metasta...

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Detalles Bibliográficos
Autores principales: Varotsos Vrynas, Angelos, Perea Paizal, Julia, Bakal, Chris, Au, Sam H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2021
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8318963/
https://www.ncbi.nlm.nih.gov/pubmed/34241735
http://dx.doi.org/10.1007/s10585-021-10109-8
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author Varotsos Vrynas, Angelos
Perea Paizal, Julia
Bakal, Chris
Au, Sam H.
author_facet Varotsos Vrynas, Angelos
Perea Paizal, Julia
Bakal, Chris
Au, Sam H.
author_sort Varotsos Vrynas, Angelos
collection PubMed
description The behaviour of circulating tumour cells in the microcirculation remains poorly understood. Growing evidence suggests that biomechanical adaptations and interactions with blood components, i.e. immune cells and platelets within capillary beds, may add more complexity to CTCs journey towards metastasis. Revisiting how these mediators impact the ability of circulating tumour cells to survive and metastasise, will be vital to understand the role of microcirculation and advance our knowledge on metastasis.
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spelling pubmed-83189632021-08-13 Arresting metastasis within the microcirculation Varotsos Vrynas, Angelos Perea Paizal, Julia Bakal, Chris Au, Sam H. Clin Exp Metastasis Commentary The behaviour of circulating tumour cells in the microcirculation remains poorly understood. Growing evidence suggests that biomechanical adaptations and interactions with blood components, i.e. immune cells and platelets within capillary beds, may add more complexity to CTCs journey towards metastasis. Revisiting how these mediators impact the ability of circulating tumour cells to survive and metastasise, will be vital to understand the role of microcirculation and advance our knowledge on metastasis. Springer Netherlands 2021-07-09 2021 /pmc/articles/PMC8318963/ /pubmed/34241735 http://dx.doi.org/10.1007/s10585-021-10109-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Commentary
Varotsos Vrynas, Angelos
Perea Paizal, Julia
Bakal, Chris
Au, Sam H.
Arresting metastasis within the microcirculation
title Arresting metastasis within the microcirculation
title_full Arresting metastasis within the microcirculation
title_fullStr Arresting metastasis within the microcirculation
title_full_unstemmed Arresting metastasis within the microcirculation
title_short Arresting metastasis within the microcirculation
title_sort arresting metastasis within the microcirculation
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8318963/
https://www.ncbi.nlm.nih.gov/pubmed/34241735
http://dx.doi.org/10.1007/s10585-021-10109-8
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