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Conformational flexibility determines the Nf2/merlin tumor suppressor functions

The Neurofibromatosis type 2 gene encodes the Nf2/merlin tumor suppressor protein that is responsible for the regulation of cell proliferation. Once activated, Nf2/merlin modulates adhesive signaling pathways and thereby inhibits cell growth. Nf2/merlin controls oncogenic gene expression by modulati...

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Detalles Bibliográficos
Autores principales:	Primi, Marina C., Rangarajan, Erumbi S., Patil, Dipak N., Izard, Tina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Special Section on Molecular and Supramolecular structure of the extracellular matrix; Edited by Sylvie Ricard-Blum.
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8318988/ https://www.ncbi.nlm.nih.gov/pubmed/34337379 http://dx.doi.org/10.1016/j.mbplus.2021.100074

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