Cargando…

Precision Neoantigen Discovery Using Large-scale Immunopeptidomes and Composite Modeling of MHC Peptide Presentation

Major histocompatibility complex (MHC)-bound peptides that originate from tumor-specific genetic alterations, known as neoantigens, are an important class of anticancer therapeutic targets. Accurately predicting peptide presentation by MHC complexes is a key aspect of discovering therapeutically rel...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pyke, Rachel Marty, Mellacheruvu, Dattatreya, Dea, Steven, Abbott, Charles W., Zhang, Simo V., Phillips, Nick A., Harris, Jason, Bartha, Gabor, Desai, Sejal, McClory, Rena, West, John, Snyder, Michael P., Chen, Richard, Boyle, Sean Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Technological Innovation and Resources
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8318994/ https://www.ncbi.nlm.nih.gov/pubmed/34126241 http://dx.doi.org/10.1016/j.mcpro.2021.100111

Ejemplares similares

MhcVizPipe: A Quality Control Software for Rapid Assessment of Small- to Large-Scale Immunopeptidome Datasets
por: Kovalchik, Kevin A., et al.
Publicado: (2021)

Prediction of Immunotherapy Response in Melanoma through Combined Modeling of Neoantigen Burden and Immune-Related Resistance Mechanisms
por: Abbott, Charles W., et al.
Publicado: (2021)

Immunopeptidogenomics: Harnessing RNA-Seq to Illuminate the Dark Immunopeptidome
por: Scull, Katherine E., et al.
Publicado: (2021)

Sensitive, High-Throughput HLA-I and HLA-II Immunopeptidomics Using Parallel Accumulation-Serial Fragmentation Mass Spectrometry
por: Phulphagar, Kshiti Meera, et al.
Publicado: (2023)

High-throughput and Sensitive Immunopeptidomics Platform Reveals Profound Interferonγ-Mediated Remodeling of the Human Leukocyte Antigen (HLA) Ligandome
por: Chong, Chloe, et al.
Publicado: (2018)

Sensitive Immunopeptidomics by Leveraging Available Large-Scale Multi-HLA Spectral Libraries, Data-Independent Acquisition, and MS/MS Prediction
por: Pak, HuiSong, et al.
Publicado: (2021)

NNAlign_MA; MHC Peptidome Deconvolution for Accurate MHC Binding Motif Characterization and Improved T-cell Epitope Predictions
por: Alvarez, Bruno, et al.
Publicado: (2019)

Sensitive and Quantitative Detection of MHC-I Displayed Neoepitopes Using a Semiautomated Workflow and TOMAHAQ Mass Spectrometry
por: Pollock, Samuel B., et al.
Publicado: (2021)

Optimized Analytical Procedures for the Untargeted Metabolomic Profiling of Human Urine and Plasma by Combining Hydrophilic Interaction (HILIC) and Reverse-Phase Liquid Chromatography (RPLC)–Mass Spectrometry
por: Contrepois, Kévin, et al.
Publicado: (2015)

A machine learning algorithm with subclonal sensitivity reveals widespread pan-cancer human leukocyte antigen loss of heterozygosity
por: Pyke, Rachel Marty, et al.
Publicado: (2022)

Neoantigen characteristics in the context of the complete predicted MHC class I self-immunopeptidome
por: Brown, Scott D., et al.
Publicado: (2018)

Prediction of LC-MS/MS Properties of Peptides from Sequence by Deep Learning
por: Guan, Shenheng, et al.
Publicado: (2019)

Proteome-wide Analysis of Lysine Acetylation Suggests its Broad Regulatory Scope in Saccharomyces cerevisiae
por: Henriksen, Peter, et al.
Publicado: (2012)

Platform-independent and Label-free Quantitation of Proteomic Data Using MS1 Extracted Ion Chromatograms in Skyline: APPLICATION TO PROTEIN ACETYLATION AND PHOSPHORYLATION
por: Schilling, Birgit, et al.
Publicado: (2012)

Prediction of Protein Complexes in Trypanosoma brucei by Protein Correlation Profiling Mass Spectrometry and Machine Learning
por: Crozier, Thomas W. M., et al.
Publicado: (2017)

pyQms enables universal and accurate quantification of mass spectrometry data
por: Leufken, Johannes, et al.
Publicado: (2017)

A Proteomic Approach to Analyze the Aspirin-mediated Lysine Acetylome
por: Tatham, Michael H., et al.
Publicado: (2017)

Global Membrane Protein Interactome Analysis using In vivo Crosslinking and Mass Spectrometry-based Protein Correlation Profiling
por: Larance, Mark, et al.
Publicado: (2016)

The One Hour Yeast Proteome
por: Hebert, Alexander S., et al.
Publicado: (2014)

ProAlanase is an Effective Alternative to Trypsin for Proteomics Applications and Disulfide Bond Mapping
por: Samodova, Diana, et al.
Publicado: (2020)

A Chemical Acetylation-Based Mass Spectrometry Platform for Histone Methylation Profiling
por: Zappacosta, Francesca, et al.
Publicado: (2021)

Concentration Determination of >200 Proteins in Dried Blood Spots for Biomarker Discovery and Validation
por: Eshghi, Azad, et al.
Publicado: (2020)

Pitfalls in HLA Ligandomics—How to Catch a Li(e)gand
por: Fritsche, Jens, et al.
Publicado: (2021)

A Standardized and Reproducible Workflow for Membrane Glass Slides in Routine Histology and Spatial Proteomics
por: Nordmann, Thierry M., et al.
Publicado: (2023)

Multiple Protein Analysis of Formalin-fixed and Paraffin-embedded Tissue Samples with Reverse phase Protein Arrays
por: Assadi, Maziar, et al.
Publicado: (2013)

Online Parallel Accumulation–Serial Fragmentation (PASEF) with a Novel Trapped Ion Mobility Mass Spectrometer
por: Meier, Florian, et al.
Publicado: (2018)

Immunoaffinity Enrichment and Mass Spectrometry Analysis of Protein Methylation
por: Guo, Ailan, et al.
Publicado: (2014)

The Human PDZome: A Gateway to PSD95-Disc Large-Zonula Occludens (PDZ)-mediated Functions
por: Belotti, Edwige, et al.
Publicado: (2013)

A High Through-put Platform for Recombinant Antibodies to Folded Proteins
por: Hornsby, Michael, et al.
Publicado: (2015)

Targeted Peptide Measurements in Biology and Medicine: Best Practices for Mass Spectrometry-based Assay Development Using a Fit-for-Purpose Approach
por: Carr, Steven A., et al.
Publicado: (2014)

In Vivo Analysis of Proteomes and Interactomes Using Parallel Affinity Capture (iPAC) Coupled to Mass Spectrometry
por: Rees, Johanna S., et al.
Publicado: (2011)

Inferring Physical Protein Contacts from Large-Scale Purification Data of Protein Complexes
por: Schelhorn, Sven-Eric, et al.
Publicado: (2011)

Published and Perished? The Influence of the Searched Protein Database on the Long-Term Storage of Proteomics Data
por: Griss, Johannes, et al.
Publicado: (2011)

Spectrum-to-Spectrum Searching Using a Proteome-wide Spectral Library
por: Yen, Chia-Yu, et al.
Publicado: (2011)

Deep and Highly Sensitive Proteome Coverage by LC-MS/MS Without Prefractionation
por: Thakur, Suman S., et al.
Publicado: (2011)

PEAKS DB: De Novo Sequencing Assisted Database Search for Sensitive and Accurate Peptide Identification
por: Zhang, Jing, et al.
Publicado: (2012)

Antibody Colocalization Microarray: A Scalable Technology for Multiplex Protein Analysis in Complex Samples
por: Pla-Roca, M., et al.
Publicado: (2012)

TraML—A Standard Format for Exchange of Selected Reaction Monitoring Transition Lists
por: Deutsch, Eric W., et al.
Publicado: (2012)

Proteomic Analysis and Discovery Using Affinity Proteomics and Mass Spectrometry
por: Olsson, Niclas, et al.
Publicado: (2011)

High Throughput Isolation and Glycosylation Analysis of IgG–Variability and Heritability of the IgG Glycome in Three Isolated Human Populations
por: Pučić, Maja, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_v7qbvpc29er8710ve1auhk51cl