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MR imaging of hypothalamic hamartoma in a patient with gelastic seizures
Hypothalamic hamartomas (HHs) are non-neoplastic malformations that occur in the region of the hypothalamus. HH is the leading cause of gelastic seizures in children and adolescents, where laughing is characteristically manifested. However, these patients can also experience different forms of compl...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8319011/ https://www.ncbi.nlm.nih.gov/pubmed/34345334 http://dx.doi.org/10.1016/j.radcr.2021.06.061 |
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author | Wan Chek, Wan Ahmad Firdaus Teh, Yong Guang Eddy Suryono, Dian Noriza Ng, Chiak Yot Ahmed, Selim |
author_facet | Wan Chek, Wan Ahmad Firdaus Teh, Yong Guang Eddy Suryono, Dian Noriza Ng, Chiak Yot Ahmed, Selim |
author_sort | Wan Chek, Wan Ahmad Firdaus |
collection | PubMed |
description | Hypothalamic hamartomas (HHs) are non-neoplastic malformations that occur in the region of the hypothalamus. HH is the leading cause of gelastic seizures in children and adolescents, where laughing is characteristically manifested. However, these patients can also experience different forms of complex or generalized tonic-clonic seizures that can obscure the diagnosis of HHs. We present a case of a 10 year-old boy that experienced several seizure types, but was subsequently diagnosed with HH after MR imaging was performed. This case highlights the complementary role of MR imaging in ascertaining seizure etiololgy when the clinical history and EEG findings are non-specific. The importance of early diagnosis with MR imaging is further underscored by the fact that patients diagnosed with HH usually develop drug resistance towards antiepileptic drugs, mandating neurosurgical assessment and intervention. |
format | Online Article Text |
id | pubmed-8319011 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-83190112021-08-02 MR imaging of hypothalamic hamartoma in a patient with gelastic seizures Wan Chek, Wan Ahmad Firdaus Teh, Yong Guang Eddy Suryono, Dian Noriza Ng, Chiak Yot Ahmed, Selim Radiol Case Rep Case Report Hypothalamic hamartomas (HHs) are non-neoplastic malformations that occur in the region of the hypothalamus. HH is the leading cause of gelastic seizures in children and adolescents, where laughing is characteristically manifested. However, these patients can also experience different forms of complex or generalized tonic-clonic seizures that can obscure the diagnosis of HHs. We present a case of a 10 year-old boy that experienced several seizure types, but was subsequently diagnosed with HH after MR imaging was performed. This case highlights the complementary role of MR imaging in ascertaining seizure etiololgy when the clinical history and EEG findings are non-specific. The importance of early diagnosis with MR imaging is further underscored by the fact that patients diagnosed with HH usually develop drug resistance towards antiepileptic drugs, mandating neurosurgical assessment and intervention. Elsevier 2021-07-16 /pmc/articles/PMC8319011/ /pubmed/34345334 http://dx.doi.org/10.1016/j.radcr.2021.06.061 Text en © 2021 The Authors. Published by Elsevier Inc. on behalf of University of Washington. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Wan Chek, Wan Ahmad Firdaus Teh, Yong Guang Eddy Suryono, Dian Noriza Ng, Chiak Yot Ahmed, Selim MR imaging of hypothalamic hamartoma in a patient with gelastic seizures |
title | MR imaging of hypothalamic hamartoma in a patient with gelastic seizures |
title_full | MR imaging of hypothalamic hamartoma in a patient with gelastic seizures |
title_fullStr | MR imaging of hypothalamic hamartoma in a patient with gelastic seizures |
title_full_unstemmed | MR imaging of hypothalamic hamartoma in a patient with gelastic seizures |
title_short | MR imaging of hypothalamic hamartoma in a patient with gelastic seizures |
title_sort | mr imaging of hypothalamic hamartoma in a patient with gelastic seizures |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8319011/ https://www.ncbi.nlm.nih.gov/pubmed/34345334 http://dx.doi.org/10.1016/j.radcr.2021.06.061 |
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