A phenotypic high-content, high-throughput screen identifies inhibitors of NLRP3 inflammasome activation

Inhibition of the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome has recently emerged as a promising therapeutic target for several inflammatory diseases. After priming and activation by inflammation triggers, NLRP3 forms a complex with apoptosis-associated speck-like protein c...

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Detalles Bibliográficos
Autores principales: Nizami, Sohaib, Millar, Val, Arunasalam, Kanisa, Zarganes-Tzitzikas, Tryfon, Brough, David, Tresadern, Gary, Brennan, Paul E., Davis, John B., Ebner, Daniel, Di Daniel, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8319173/
https://www.ncbi.nlm.nih.gov/pubmed/34321581
http://dx.doi.org/10.1038/s41598-021-94850-w

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