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Trends in type 2 diabetes mellitus disease burden in European Union countries between 1990 and 2019
This observational study aimed to assess trends in type 2 diabetes mellitus (T2DM) disease burden in European Union countries for the years 1990–2019. Sex specific T2DM age-standardised prevalence (ASPRs), mortality (ASMRs) and disability-adjusted life-year rates (DALYs) per 100,000 population were...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8319179/ https://www.ncbi.nlm.nih.gov/pubmed/34321515 http://dx.doi.org/10.1038/s41598-021-94807-z |
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author | Goodall, Richard Alazawi, Andrew Hughes, Will Bravis, Vassiliki Salciccioli, Justin D. Marshall, Dominic C. Crowley, Conor Shalhoub, Joseph |
author_facet | Goodall, Richard Alazawi, Andrew Hughes, Will Bravis, Vassiliki Salciccioli, Justin D. Marshall, Dominic C. Crowley, Conor Shalhoub, Joseph |
author_sort | Goodall, Richard |
collection | PubMed |
description | This observational study aimed to assess trends in type 2 diabetes mellitus (T2DM) disease burden in European Union countries for the years 1990–2019. Sex specific T2DM age-standardised prevalence (ASPRs), mortality (ASMRs) and disability-adjusted life-year rates (DALYs) per 100,000 population were extracted from the Global Burden of Disease (GBD) Study online results tool for each EU country (inclusive of the United Kingdom), for the years 1990–2019. Trends were analysed using Joinpoint regression analysis. Between 1990 and 2019, increases in T2DM ASPRs were observed for all EU countries. The highest relative increases in ASPRs were observed in Luxembourg (males + 269.1%, females + 219.2%), Ireland (males + 191.9%, females + 165.7%) and the UK (males + 128.6%, females + 114.6%). Mortality trends were less uniform across EU countries, however a general trend towards reducing T2DM mortality was observed, with ASMRs decreasing over the 30-year period studied in 16/28 countries for males and in 24/28 countries for females. The UK observed the highest relative decrease in ASMRs for males (− 46.9%). For females, the largest relative decrease in ASMRs was in Cyprus (− 67.6%). DALYs increased in 25/28 countries for males and in 17/28 countries for females between 1990 and 2019. DALYs were higher in males than females in all EU countries in 2019. T2DM prevalence rates have increased across EU countries over the last 30 years. Mortality from T2DM has generally decreased in EU countries, however trends were more variable than those observed for prevalence. Primary prevention strategies should continue to be a focus for preventing T2DM in at risk groups in EU countries. |
format | Online Article Text |
id | pubmed-8319179 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-83191792021-07-29 Trends in type 2 diabetes mellitus disease burden in European Union countries between 1990 and 2019 Goodall, Richard Alazawi, Andrew Hughes, Will Bravis, Vassiliki Salciccioli, Justin D. Marshall, Dominic C. Crowley, Conor Shalhoub, Joseph Sci Rep Article This observational study aimed to assess trends in type 2 diabetes mellitus (T2DM) disease burden in European Union countries for the years 1990–2019. Sex specific T2DM age-standardised prevalence (ASPRs), mortality (ASMRs) and disability-adjusted life-year rates (DALYs) per 100,000 population were extracted from the Global Burden of Disease (GBD) Study online results tool for each EU country (inclusive of the United Kingdom), for the years 1990–2019. Trends were analysed using Joinpoint regression analysis. Between 1990 and 2019, increases in T2DM ASPRs were observed for all EU countries. The highest relative increases in ASPRs were observed in Luxembourg (males + 269.1%, females + 219.2%), Ireland (males + 191.9%, females + 165.7%) and the UK (males + 128.6%, females + 114.6%). Mortality trends were less uniform across EU countries, however a general trend towards reducing T2DM mortality was observed, with ASMRs decreasing over the 30-year period studied in 16/28 countries for males and in 24/28 countries for females. The UK observed the highest relative decrease in ASMRs for males (− 46.9%). For females, the largest relative decrease in ASMRs was in Cyprus (− 67.6%). DALYs increased in 25/28 countries for males and in 17/28 countries for females between 1990 and 2019. DALYs were higher in males than females in all EU countries in 2019. T2DM prevalence rates have increased across EU countries over the last 30 years. Mortality from T2DM has generally decreased in EU countries, however trends were more variable than those observed for prevalence. Primary prevention strategies should continue to be a focus for preventing T2DM in at risk groups in EU countries. Nature Publishing Group UK 2021-07-28 /pmc/articles/PMC8319179/ /pubmed/34321515 http://dx.doi.org/10.1038/s41598-021-94807-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Goodall, Richard Alazawi, Andrew Hughes, Will Bravis, Vassiliki Salciccioli, Justin D. Marshall, Dominic C. Crowley, Conor Shalhoub, Joseph Trends in type 2 diabetes mellitus disease burden in European Union countries between 1990 and 2019 |
title | Trends in type 2 diabetes mellitus disease burden in European Union countries between 1990 and 2019 |
title_full | Trends in type 2 diabetes mellitus disease burden in European Union countries between 1990 and 2019 |
title_fullStr | Trends in type 2 diabetes mellitus disease burden in European Union countries between 1990 and 2019 |
title_full_unstemmed | Trends in type 2 diabetes mellitus disease burden in European Union countries between 1990 and 2019 |
title_short | Trends in type 2 diabetes mellitus disease burden in European Union countries between 1990 and 2019 |
title_sort | trends in type 2 diabetes mellitus disease burden in european union countries between 1990 and 2019 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8319179/ https://www.ncbi.nlm.nih.gov/pubmed/34321515 http://dx.doi.org/10.1038/s41598-021-94807-z |
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