PALI1 facilitates DNA and nucleosome binding by PRC2 and triggers an allosteric activation of catalysis

The polycomb repressive complex 2 (PRC2) is a histone methyltransferase that maintains cell identities. JARID2 is the only accessory subunit of PRC2 that known to trigger an allosteric activation of methyltransferase. Yet, this mechanism cannot be generalised to all PRC2 variants as, in vertebrates,...

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Detalles Bibliográficos
Autores principales: Zhang, Qi, Agius, Samuel C., Flanigan, Sarena F., Uckelmann, Michael, Levina, Vitalina, Owen, Brady M., Davidovich, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8319299/
https://www.ncbi.nlm.nih.gov/pubmed/34321472
http://dx.doi.org/10.1038/s41467-021-24866-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8319299/
https://www.ncbi.nlm.nih.gov/pubmed/34321472
http://dx.doi.org/10.1038/s41467-021-24866-3

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