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Synergistic epistasis enhances the co-operativity of mutualistic interspecies interactions
Early evolution of mutualism is characterized by big and predictable adaptive changes, including the specialization of interacting partners, such as through deleterious mutations in genes not required for metabolic cross-feeding. We sought to investigate whether these early mutations improve coopera...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8319347/ https://www.ncbi.nlm.nih.gov/pubmed/33612833 http://dx.doi.org/10.1038/s41396-021-00919-9 |
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author | Turkarslan, Serdar Stopnisek, Nejc Thompson, Anne W. Arens, Christina E. Valenzuela, Jacob J. Wilson, James Hunt, Kristopher A. Hardwicke, Jessica de Lomana, Adrián López García Lim, Sujung Seah, Yee Mey Fu, Ying Wu, Liyou Zhou, Jizhong Hillesland, Kristina L. Stahl, David A. Baliga, Nitin S. |
author_facet | Turkarslan, Serdar Stopnisek, Nejc Thompson, Anne W. Arens, Christina E. Valenzuela, Jacob J. Wilson, James Hunt, Kristopher A. Hardwicke, Jessica de Lomana, Adrián López García Lim, Sujung Seah, Yee Mey Fu, Ying Wu, Liyou Zhou, Jizhong Hillesland, Kristina L. Stahl, David A. Baliga, Nitin S. |
author_sort | Turkarslan, Serdar |
collection | PubMed |
description | Early evolution of mutualism is characterized by big and predictable adaptive changes, including the specialization of interacting partners, such as through deleterious mutations in genes not required for metabolic cross-feeding. We sought to investigate whether these early mutations improve cooperativity by manifesting in synergistic epistasis between genomes of the mutually interacting species. Specifically, we have characterized evolutionary trajectories of syntrophic interactions of Desulfovibrio vulgaris (Dv) with Methanococcus maripaludis (Mm) by longitudinally monitoring mutations accumulated over 1000 generations of nine independently evolved communities with analysis of the genotypic structure of one community down to the single-cell level. We discovered extensive parallelism across communities despite considerable variance in their evolutionary trajectories and the perseverance within many evolution lines of a rare lineage of Dv that retained sulfate-respiration (SR+) capability, which is not required for metabolic cross-feeding. An in-depth investigation revealed that synergistic epistasis across pairings of Dv and Mm genotypes had enhanced cooperativity within SR− and SR+ assemblages, enabling their coexistence within the same community. Thus, our findings demonstrate that cooperativity of a mutualism can improve through synergistic epistasis between genomes of the interacting species, enabling the coexistence of mutualistic assemblages of generalists and their specialized variants. |
format | Online Article Text |
id | pubmed-8319347 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-83193472021-08-02 Synergistic epistasis enhances the co-operativity of mutualistic interspecies interactions Turkarslan, Serdar Stopnisek, Nejc Thompson, Anne W. Arens, Christina E. Valenzuela, Jacob J. Wilson, James Hunt, Kristopher A. Hardwicke, Jessica de Lomana, Adrián López García Lim, Sujung Seah, Yee Mey Fu, Ying Wu, Liyou Zhou, Jizhong Hillesland, Kristina L. Stahl, David A. Baliga, Nitin S. ISME J Article Early evolution of mutualism is characterized by big and predictable adaptive changes, including the specialization of interacting partners, such as through deleterious mutations in genes not required for metabolic cross-feeding. We sought to investigate whether these early mutations improve cooperativity by manifesting in synergistic epistasis between genomes of the mutually interacting species. Specifically, we have characterized evolutionary trajectories of syntrophic interactions of Desulfovibrio vulgaris (Dv) with Methanococcus maripaludis (Mm) by longitudinally monitoring mutations accumulated over 1000 generations of nine independently evolved communities with analysis of the genotypic structure of one community down to the single-cell level. We discovered extensive parallelism across communities despite considerable variance in their evolutionary trajectories and the perseverance within many evolution lines of a rare lineage of Dv that retained sulfate-respiration (SR+) capability, which is not required for metabolic cross-feeding. An in-depth investigation revealed that synergistic epistasis across pairings of Dv and Mm genotypes had enhanced cooperativity within SR− and SR+ assemblages, enabling their coexistence within the same community. Thus, our findings demonstrate that cooperativity of a mutualism can improve through synergistic epistasis between genomes of the interacting species, enabling the coexistence of mutualistic assemblages of generalists and their specialized variants. Nature Publishing Group UK 2021-02-21 2021-08 /pmc/articles/PMC8319347/ /pubmed/33612833 http://dx.doi.org/10.1038/s41396-021-00919-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Turkarslan, Serdar Stopnisek, Nejc Thompson, Anne W. Arens, Christina E. Valenzuela, Jacob J. Wilson, James Hunt, Kristopher A. Hardwicke, Jessica de Lomana, Adrián López García Lim, Sujung Seah, Yee Mey Fu, Ying Wu, Liyou Zhou, Jizhong Hillesland, Kristina L. Stahl, David A. Baliga, Nitin S. Synergistic epistasis enhances the co-operativity of mutualistic interspecies interactions |
title | Synergistic epistasis enhances the co-operativity of mutualistic interspecies interactions |
title_full | Synergistic epistasis enhances the co-operativity of mutualistic interspecies interactions |
title_fullStr | Synergistic epistasis enhances the co-operativity of mutualistic interspecies interactions |
title_full_unstemmed | Synergistic epistasis enhances the co-operativity of mutualistic interspecies interactions |
title_short | Synergistic epistasis enhances the co-operativity of mutualistic interspecies interactions |
title_sort | synergistic epistasis enhances the co-operativity of mutualistic interspecies interactions |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8319347/ https://www.ncbi.nlm.nih.gov/pubmed/33612833 http://dx.doi.org/10.1038/s41396-021-00919-9 |
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