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Elevations in Liver Transaminases in COVID-19: (How) Are They Related?
Liver involvement in COVID-19 is not yet well-understood, but elevations in liver transaminases have been described to occur in 14–53% of the cases and are more frequently seen in severe disease. This cross-sectional study explored the relationship between the elevations in liver transaminases and i...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8319468/ https://www.ncbi.nlm.nih.gov/pubmed/34336904 http://dx.doi.org/10.3389/fmed.2021.705247 |
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author | Pott-Junior, Henrique Bittencourt, Natália Queiroz Prado Chacha, Silvana F. G. Luporini, Rafael Luís Cominetti, Marcia Regina Anibal, Fernanda de Freitas |
author_facet | Pott-Junior, Henrique Bittencourt, Natália Queiroz Prado Chacha, Silvana F. G. Luporini, Rafael Luís Cominetti, Marcia Regina Anibal, Fernanda de Freitas |
author_sort | Pott-Junior, Henrique |
collection | PubMed |
description | Liver involvement in COVID-19 is not yet well-understood, but elevations in liver transaminases have been described to occur in 14–53% of the cases and are more frequently seen in severe disease. This cross-sectional study explored the relationship between the elevations in liver transaminases and inflammatory parameters in 209 adults with COVID-19. Demographic and clinical data, serum levels of inflammatory cytokines and liver aminotransferases were analyzed. Three groups were formed according to the liver transaminase abnormalities: (I) Normal transaminases, (II) Borderline transaminases elevation, and (III) Mild to severe transaminases elevation. Altered liver transaminases were directly related to disease severity, showing association with the NEWS2 score at admission and greater need for ICU or death. Moreover, higher levels of IL-2 and CRP were associated with borderline transaminases elevations, whereas higher levels of IL-10 and Neutrophil to Lymphocyte ratio were associated with mild to severe transaminases elevation. These results reinforce the importance of liver transaminases in patients with COVID-19 as a complementary marker for disease severity and also point to them as a parameter reflecting the continuous dynamics between viral infection and the immune response. |
format | Online Article Text |
id | pubmed-8319468 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83194682021-07-30 Elevations in Liver Transaminases in COVID-19: (How) Are They Related? Pott-Junior, Henrique Bittencourt, Natália Queiroz Prado Chacha, Silvana F. G. Luporini, Rafael Luís Cominetti, Marcia Regina Anibal, Fernanda de Freitas Front Med (Lausanne) Medicine Liver involvement in COVID-19 is not yet well-understood, but elevations in liver transaminases have been described to occur in 14–53% of the cases and are more frequently seen in severe disease. This cross-sectional study explored the relationship between the elevations in liver transaminases and inflammatory parameters in 209 adults with COVID-19. Demographic and clinical data, serum levels of inflammatory cytokines and liver aminotransferases were analyzed. Three groups were formed according to the liver transaminase abnormalities: (I) Normal transaminases, (II) Borderline transaminases elevation, and (III) Mild to severe transaminases elevation. Altered liver transaminases were directly related to disease severity, showing association with the NEWS2 score at admission and greater need for ICU or death. Moreover, higher levels of IL-2 and CRP were associated with borderline transaminases elevations, whereas higher levels of IL-10 and Neutrophil to Lymphocyte ratio were associated with mild to severe transaminases elevation. These results reinforce the importance of liver transaminases in patients with COVID-19 as a complementary marker for disease severity and also point to them as a parameter reflecting the continuous dynamics between viral infection and the immune response. Frontiers Media S.A. 2021-07-15 /pmc/articles/PMC8319468/ /pubmed/34336904 http://dx.doi.org/10.3389/fmed.2021.705247 Text en Copyright © 2021 Pott-Junior, Bittencourt, Chacha, Luporini, Cominetti and Anibal. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Pott-Junior, Henrique Bittencourt, Natália Queiroz Prado Chacha, Silvana F. G. Luporini, Rafael Luís Cominetti, Marcia Regina Anibal, Fernanda de Freitas Elevations in Liver Transaminases in COVID-19: (How) Are They Related? |
title | Elevations in Liver Transaminases in COVID-19: (How) Are They Related? |
title_full | Elevations in Liver Transaminases in COVID-19: (How) Are They Related? |
title_fullStr | Elevations in Liver Transaminases in COVID-19: (How) Are They Related? |
title_full_unstemmed | Elevations in Liver Transaminases in COVID-19: (How) Are They Related? |
title_short | Elevations in Liver Transaminases in COVID-19: (How) Are They Related? |
title_sort | elevations in liver transaminases in covid-19: (how) are they related? |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8319468/ https://www.ncbi.nlm.nih.gov/pubmed/34336904 http://dx.doi.org/10.3389/fmed.2021.705247 |
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