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Elevations in Liver Transaminases in COVID-19: (How) Are They Related?

Liver involvement in COVID-19 is not yet well-understood, but elevations in liver transaminases have been described to occur in 14–53% of the cases and are more frequently seen in severe disease. This cross-sectional study explored the relationship between the elevations in liver transaminases and i...

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Autores principales: Pott-Junior, Henrique, Bittencourt, Natália Queiroz Prado, Chacha, Silvana F. G., Luporini, Rafael Luís, Cominetti, Marcia Regina, Anibal, Fernanda de Freitas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8319468/
https://www.ncbi.nlm.nih.gov/pubmed/34336904
http://dx.doi.org/10.3389/fmed.2021.705247
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author Pott-Junior, Henrique
Bittencourt, Natália Queiroz Prado
Chacha, Silvana F. G.
Luporini, Rafael Luís
Cominetti, Marcia Regina
Anibal, Fernanda de Freitas
author_facet Pott-Junior, Henrique
Bittencourt, Natália Queiroz Prado
Chacha, Silvana F. G.
Luporini, Rafael Luís
Cominetti, Marcia Regina
Anibal, Fernanda de Freitas
author_sort Pott-Junior, Henrique
collection PubMed
description Liver involvement in COVID-19 is not yet well-understood, but elevations in liver transaminases have been described to occur in 14–53% of the cases and are more frequently seen in severe disease. This cross-sectional study explored the relationship between the elevations in liver transaminases and inflammatory parameters in 209 adults with COVID-19. Demographic and clinical data, serum levels of inflammatory cytokines and liver aminotransferases were analyzed. Three groups were formed according to the liver transaminase abnormalities: (I) Normal transaminases, (II) Borderline transaminases elevation, and (III) Mild to severe transaminases elevation. Altered liver transaminases were directly related to disease severity, showing association with the NEWS2 score at admission and greater need for ICU or death. Moreover, higher levels of IL-2 and CRP were associated with borderline transaminases elevations, whereas higher levels of IL-10 and Neutrophil to Lymphocyte ratio were associated with mild to severe transaminases elevation. These results reinforce the importance of liver transaminases in patients with COVID-19 as a complementary marker for disease severity and also point to them as a parameter reflecting the continuous dynamics between viral infection and the immune response.
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spelling pubmed-83194682021-07-30 Elevations in Liver Transaminases in COVID-19: (How) Are They Related? Pott-Junior, Henrique Bittencourt, Natália Queiroz Prado Chacha, Silvana F. G. Luporini, Rafael Luís Cominetti, Marcia Regina Anibal, Fernanda de Freitas Front Med (Lausanne) Medicine Liver involvement in COVID-19 is not yet well-understood, but elevations in liver transaminases have been described to occur in 14–53% of the cases and are more frequently seen in severe disease. This cross-sectional study explored the relationship between the elevations in liver transaminases and inflammatory parameters in 209 adults with COVID-19. Demographic and clinical data, serum levels of inflammatory cytokines and liver aminotransferases were analyzed. Three groups were formed according to the liver transaminase abnormalities: (I) Normal transaminases, (II) Borderline transaminases elevation, and (III) Mild to severe transaminases elevation. Altered liver transaminases were directly related to disease severity, showing association with the NEWS2 score at admission and greater need for ICU or death. Moreover, higher levels of IL-2 and CRP were associated with borderline transaminases elevations, whereas higher levels of IL-10 and Neutrophil to Lymphocyte ratio were associated with mild to severe transaminases elevation. These results reinforce the importance of liver transaminases in patients with COVID-19 as a complementary marker for disease severity and also point to them as a parameter reflecting the continuous dynamics between viral infection and the immune response. Frontiers Media S.A. 2021-07-15 /pmc/articles/PMC8319468/ /pubmed/34336904 http://dx.doi.org/10.3389/fmed.2021.705247 Text en Copyright © 2021 Pott-Junior, Bittencourt, Chacha, Luporini, Cominetti and Anibal. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Pott-Junior, Henrique
Bittencourt, Natália Queiroz Prado
Chacha, Silvana F. G.
Luporini, Rafael Luís
Cominetti, Marcia Regina
Anibal, Fernanda de Freitas
Elevations in Liver Transaminases in COVID-19: (How) Are They Related?
title Elevations in Liver Transaminases in COVID-19: (How) Are They Related?
title_full Elevations in Liver Transaminases in COVID-19: (How) Are They Related?
title_fullStr Elevations in Liver Transaminases in COVID-19: (How) Are They Related?
title_full_unstemmed Elevations in Liver Transaminases in COVID-19: (How) Are They Related?
title_short Elevations in Liver Transaminases in COVID-19: (How) Are They Related?
title_sort elevations in liver transaminases in covid-19: (how) are they related?
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8319468/
https://www.ncbi.nlm.nih.gov/pubmed/34336904
http://dx.doi.org/10.3389/fmed.2021.705247
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