Human and viral membrane–associated E3 ubiquitin ligases MARCH1 and MIR2 recognize different features of CD86 to downregulate surface expression

Immune-stimulatory ligands, such as major histocompatibility complex molecules and the T-cell costimulatory ligand CD86, are central to productive immunity. Endogenous mammalian membrane-associated RING-CHs (MARCH) act on these and other targets to regulate antigen presentation and activation of ada...

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Detalles Bibliográficos
Autores principales: Trenker, Raphael, Wu, Xinyu, Nguyen, Julie V., Wilcox, Stephen, Rubin, Alan F., Call, Matthew E., Call, Melissa J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8319528/
https://www.ncbi.nlm.nih.gov/pubmed/34157285
http://dx.doi.org/10.1016/j.jbc.2021.100900

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