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Prognostic Significance of Signet-Ring Cell Components in Patients With Gastric Carcinoma of Different Stages
Background: Gastric carcinoma (GC), which contains signet ring cell (SRC) components are frequently observed in postoperative pathological assessment. This study aims to study the prognostic significance of SRC components in GC patients. Methods: From 2003 to 2017, surgically resected primary GC pat...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8319562/ https://www.ncbi.nlm.nih.gov/pubmed/34336913 http://dx.doi.org/10.3389/fsurg.2021.642468 |
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author | Dong, Xiaoyuan Sun, Guorui Qu, Hui He, Qingsi Hao, Zhaofan |
author_facet | Dong, Xiaoyuan Sun, Guorui Qu, Hui He, Qingsi Hao, Zhaofan |
author_sort | Dong, Xiaoyuan |
collection | PubMed |
description | Background: Gastric carcinoma (GC), which contains signet ring cell (SRC) components are frequently observed in postoperative pathological assessment. This study aims to study the prognostic significance of SRC components in GC patients. Methods: From 2003 to 2017, surgically resected primary GC patients were retrospectively reviewed. All enrolled patients were divided into three groups according to the proportion of SRC. The overall survival (OS) and disease-free survival (DFS) of GC patients with different tumor stages were analyzed. Results: Patients with SRC or mixed-SRC were more associated with female, younger age, middle or lower third of the stomach, larger tumor, higher pN stage, and more lymphovascular invasion. For GC patients in stage I, multivariate survival analysis showed that age >60, SRC components >50%, and pT stage were independent prognostic factors for OS (all p < 0.05). The 5-year OS of patients with SRC were higher than that of patients with pure adenocarcinoma (p = 0.021). For GC patients in stage II/III, multivariate survival analysis showed that age >60, SRC proportion, surgical types, Borrmann's type, pT stage, pN stage, and lymphovascular invasion were independent prognostic factors for OS (all p < 0.05). The 5-year OS/DFS of patients with SRC were lower than that of patients with pure adenocarcinoma (p < 0.001). Conclusions: SRC seemed to be a favorable prognostic factor in GC patients in stage I. However, for GC patients in stage II/III, the SRC components were associated with poor prognosis, independent of other clinicopathological factors. |
format | Online Article Text |
id | pubmed-8319562 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83195622021-07-30 Prognostic Significance of Signet-Ring Cell Components in Patients With Gastric Carcinoma of Different Stages Dong, Xiaoyuan Sun, Guorui Qu, Hui He, Qingsi Hao, Zhaofan Front Surg Surgery Background: Gastric carcinoma (GC), which contains signet ring cell (SRC) components are frequently observed in postoperative pathological assessment. This study aims to study the prognostic significance of SRC components in GC patients. Methods: From 2003 to 2017, surgically resected primary GC patients were retrospectively reviewed. All enrolled patients were divided into three groups according to the proportion of SRC. The overall survival (OS) and disease-free survival (DFS) of GC patients with different tumor stages were analyzed. Results: Patients with SRC or mixed-SRC were more associated with female, younger age, middle or lower third of the stomach, larger tumor, higher pN stage, and more lymphovascular invasion. For GC patients in stage I, multivariate survival analysis showed that age >60, SRC components >50%, and pT stage were independent prognostic factors for OS (all p < 0.05). The 5-year OS of patients with SRC were higher than that of patients with pure adenocarcinoma (p = 0.021). For GC patients in stage II/III, multivariate survival analysis showed that age >60, SRC proportion, surgical types, Borrmann's type, pT stage, pN stage, and lymphovascular invasion were independent prognostic factors for OS (all p < 0.05). The 5-year OS/DFS of patients with SRC were lower than that of patients with pure adenocarcinoma (p < 0.001). Conclusions: SRC seemed to be a favorable prognostic factor in GC patients in stage I. However, for GC patients in stage II/III, the SRC components were associated with poor prognosis, independent of other clinicopathological factors. Frontiers Media S.A. 2021-07-15 /pmc/articles/PMC8319562/ /pubmed/34336913 http://dx.doi.org/10.3389/fsurg.2021.642468 Text en Copyright © 2021 Dong, Sun, Qu, He and Hao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Surgery Dong, Xiaoyuan Sun, Guorui Qu, Hui He, Qingsi Hao, Zhaofan Prognostic Significance of Signet-Ring Cell Components in Patients With Gastric Carcinoma of Different Stages |
title | Prognostic Significance of Signet-Ring Cell Components in Patients With Gastric Carcinoma of Different Stages |
title_full | Prognostic Significance of Signet-Ring Cell Components in Patients With Gastric Carcinoma of Different Stages |
title_fullStr | Prognostic Significance of Signet-Ring Cell Components in Patients With Gastric Carcinoma of Different Stages |
title_full_unstemmed | Prognostic Significance of Signet-Ring Cell Components in Patients With Gastric Carcinoma of Different Stages |
title_short | Prognostic Significance of Signet-Ring Cell Components in Patients With Gastric Carcinoma of Different Stages |
title_sort | prognostic significance of signet-ring cell components in patients with gastric carcinoma of different stages |
topic | Surgery |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8319562/ https://www.ncbi.nlm.nih.gov/pubmed/34336913 http://dx.doi.org/10.3389/fsurg.2021.642468 |
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