Infectious etiology and amyloidosis in Alzheimer's disease: The puzzle continues

Recent studies have renewed the debate on infectious etiology in late-onset Alzheimer's disease. Bocharova et al. reported that abundant expression of human beta amyloid (Aβ) in the mouse brain (5XFAD animals) failed to protect against acute herpes simplex virus type 1 infection relative to con...

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Autor principal: Kayed, Rakez
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Editors' Pick Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8319577/
https://www.ncbi.nlm.nih.gov/pubmed/34217702
http://dx.doi.org/10.1016/j.jbc.2021.100936
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author Kayed, Rakez
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description Recent studies have renewed the debate on infectious etiology in late-onset Alzheimer's disease. Bocharova et al. reported that abundant expression of human beta amyloid (Aβ) in the mouse brain (5XFAD animals) failed to protect against acute herpes simplex virus type 1 infection relative to control mice. While this study does not confirm the antiviral actions of Aβ, it neither supports nor disproves the hypothesis that infection with microbial pathogens is the major cause of Alzheimer's disease.
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spelling pubmed-83195772021-07-31 Infectious etiology and amyloidosis in Alzheimer's disease: The puzzle continues Kayed, Rakez J Biol Chem Editors' Pick Highlight Recent studies have renewed the debate on infectious etiology in late-onset Alzheimer's disease. Bocharova et al. reported that abundant expression of human beta amyloid (Aβ) in the mouse brain (5XFAD animals) failed to protect against acute herpes simplex virus type 1 infection relative to control mice. While this study does not confirm the antiviral actions of Aβ, it neither supports nor disproves the hypothesis that infection with microbial pathogens is the major cause of Alzheimer's disease. American Society for Biochemistry and Molecular Biology 2021-07-02 /pmc/articles/PMC8319577/ /pubmed/34217702 http://dx.doi.org/10.1016/j.jbc.2021.100936 Text en © 2021 The Author https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Editors' Pick Highlight
Kayed, Rakez
Infectious etiology and amyloidosis in Alzheimer's disease: The puzzle continues
title Infectious etiology and amyloidosis in Alzheimer's disease: The puzzle continues
title_full Infectious etiology and amyloidosis in Alzheimer's disease: The puzzle continues
title_fullStr Infectious etiology and amyloidosis in Alzheimer's disease: The puzzle continues
title_full_unstemmed Infectious etiology and amyloidosis in Alzheimer's disease: The puzzle continues
title_short Infectious etiology and amyloidosis in Alzheimer's disease: The puzzle continues
title_sort infectious etiology and amyloidosis in alzheimer's disease: the puzzle continues
topic Editors' Pick Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8319577/
https://www.ncbi.nlm.nih.gov/pubmed/34217702
http://dx.doi.org/10.1016/j.jbc.2021.100936
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