Research Progress on the Mechanism of Mitochondrial Autophagy in Cerebral Stroke

Mitochondrial autophagy is an early defense and protection process that selectively clears dysfunctional or excessive mitochondria through a distinctive mechanism to maintain intracellular homeostasis. Mitochondrial dysfunction during cerebral stroke involves metabolic disbalance, oxidative stress,...

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Detalles Bibliográficos
Autores principales: Lei, Li, Yang, Shuaifeng, Lu, Xiaoyang, Zhang, Yongfa, Li, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8319822/
https://www.ncbi.nlm.nih.gov/pubmed/34335233
http://dx.doi.org/10.3389/fnagi.2021.698601
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author Lei, Li
Yang, Shuaifeng
Lu, Xiaoyang
Zhang, Yongfa
Li, Tao
author_facet Lei, Li
Yang, Shuaifeng
Lu, Xiaoyang
Zhang, Yongfa
Li, Tao
author_sort Lei, Li
collection PubMed
description Mitochondrial autophagy is an early defense and protection process that selectively clears dysfunctional or excessive mitochondria through a distinctive mechanism to maintain intracellular homeostasis. Mitochondrial dysfunction during cerebral stroke involves metabolic disbalance, oxidative stress, apoptosis, endoplasmic reticulum stress, and abnormal mitochondrial autophagy. This article reviews the research progress on the mechanism of mitochondrial autophagy in ischemic stroke to provide a theoretical basis for further research on mitochondrial autophagy and the treatment of ischemic stroke.
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spelling pubmed-83198222021-07-30 Research Progress on the Mechanism of Mitochondrial Autophagy in Cerebral Stroke Lei, Li Yang, Shuaifeng Lu, Xiaoyang Zhang, Yongfa Li, Tao Front Aging Neurosci Neuroscience Mitochondrial autophagy is an early defense and protection process that selectively clears dysfunctional or excessive mitochondria through a distinctive mechanism to maintain intracellular homeostasis. Mitochondrial dysfunction during cerebral stroke involves metabolic disbalance, oxidative stress, apoptosis, endoplasmic reticulum stress, and abnormal mitochondrial autophagy. This article reviews the research progress on the mechanism of mitochondrial autophagy in ischemic stroke to provide a theoretical basis for further research on mitochondrial autophagy and the treatment of ischemic stroke. Frontiers Media S.A. 2021-07-15 /pmc/articles/PMC8319822/ /pubmed/34335233 http://dx.doi.org/10.3389/fnagi.2021.698601 Text en Copyright © 2021 Lei, Yang, Lu, Zhang and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Lei, Li
Yang, Shuaifeng
Lu, Xiaoyang
Zhang, Yongfa
Li, Tao
Research Progress on the Mechanism of Mitochondrial Autophagy in Cerebral Stroke
title Research Progress on the Mechanism of Mitochondrial Autophagy in Cerebral Stroke
title_full Research Progress on the Mechanism of Mitochondrial Autophagy in Cerebral Stroke
title_fullStr Research Progress on the Mechanism of Mitochondrial Autophagy in Cerebral Stroke
title_full_unstemmed Research Progress on the Mechanism of Mitochondrial Autophagy in Cerebral Stroke
title_short Research Progress on the Mechanism of Mitochondrial Autophagy in Cerebral Stroke
title_sort research progress on the mechanism of mitochondrial autophagy in cerebral stroke
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8319822/
https://www.ncbi.nlm.nih.gov/pubmed/34335233
http://dx.doi.org/10.3389/fnagi.2021.698601
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