Indole Inhibitors of MMP-13 for Arthritic Disorders

[Image: see text] Here, we described the design, by fragment merging and multiparameter optimization, of selective MMP-13 inhibitors that display an appropriate balance of potency and physicochemical properties to qualify as tool compounds suitable for in vivo testing. Optimization of potency was gu...

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Detalles Bibliográficos
Autores principales: Taylor, Steven J., Abeywardane, Asitha, Liang, Shuang, Xiong, Zhaoming, Proudfoot, John R., Farmer, Bennett Sandy, Gao, Donghong A., Heim-Riether, Alexander, Smith-Keenan, Lana Louise, Muegge, Ingo, Yu, Yang, Zhang, Qiang, Souza, Donald, Panzenbeck, Mark, Goldberg, Daniel, Hill-Drzewi, Melissa, Margarit, Mariana, Collins, Brandon, Li, John Xiang, Zuvela-Jelaska, Ljiljana, Li, Jun, Farrow, Neil A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8319936/
https://www.ncbi.nlm.nih.gov/pubmed/34337203
http://dx.doi.org/10.1021/acsomega.1c01320

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