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Is RAS the Link Between COVID-19 and Increased Stress in Head and Neck Cancer Patients?
The COVID-19 pandemic emerged as a largely unexplained outbreak of pneumonia cases, in Wuhan City, China and rapidly spread across the world. By 11th March 2020, WHO declared it as a global pandemic. The resulting restrictions, to contain its spread, demanded a momentous change in the lifestyle of t...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8320172/ https://www.ncbi.nlm.nih.gov/pubmed/34336866 http://dx.doi.org/10.3389/fcell.2021.714999 |
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author | Iftikhar, Anem Islam, Mohammad Shepherd, Simon Jones, Sarah Ellis, Ian |
author_facet | Iftikhar, Anem Islam, Mohammad Shepherd, Simon Jones, Sarah Ellis, Ian |
author_sort | Iftikhar, Anem |
collection | PubMed |
description | The COVID-19 pandemic emerged as a largely unexplained outbreak of pneumonia cases, in Wuhan City, China and rapidly spread across the world. By 11th March 2020, WHO declared it as a global pandemic. The resulting restrictions, to contain its spread, demanded a momentous change in the lifestyle of the general population as well as cancer patients. This augmented negative effects on the mental health of patients with head and neck cancer (HNC), who already battle with the stress of cancer diagnosis and treatment. The causative agent of COVID-19, SARS-CoV2, gains entry through the Angiotensin converting enzyme 2 (ACE2) receptor, which is a component of the Renin Angiotensin System (RAS). RAS has been shown to influence cancer and stress such that it can have progressive and suppressive effects on both. This review provides an overview of SARS-CoV2, looks at how the RAS provides a mechanistic link between stress, cancer and COVID-19 and the probable activation of the RAS axis that increase stress (anxiogenic) and tumor progression (tumorigenic), when ACE2 is hijacked by SARS-CoV2. The mental health crises brought about by this pandemic have been highlighted in many studies. The emerging links between cancer and stress make it more important than ever before to assess the stress burden of cancer patients and expand the strategies for its management. |
format | Online Article Text |
id | pubmed-8320172 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83201722021-07-30 Is RAS the Link Between COVID-19 and Increased Stress in Head and Neck Cancer Patients? Iftikhar, Anem Islam, Mohammad Shepherd, Simon Jones, Sarah Ellis, Ian Front Cell Dev Biol Cell and Developmental Biology The COVID-19 pandemic emerged as a largely unexplained outbreak of pneumonia cases, in Wuhan City, China and rapidly spread across the world. By 11th March 2020, WHO declared it as a global pandemic. The resulting restrictions, to contain its spread, demanded a momentous change in the lifestyle of the general population as well as cancer patients. This augmented negative effects on the mental health of patients with head and neck cancer (HNC), who already battle with the stress of cancer diagnosis and treatment. The causative agent of COVID-19, SARS-CoV2, gains entry through the Angiotensin converting enzyme 2 (ACE2) receptor, which is a component of the Renin Angiotensin System (RAS). RAS has been shown to influence cancer and stress such that it can have progressive and suppressive effects on both. This review provides an overview of SARS-CoV2, looks at how the RAS provides a mechanistic link between stress, cancer and COVID-19 and the probable activation of the RAS axis that increase stress (anxiogenic) and tumor progression (tumorigenic), when ACE2 is hijacked by SARS-CoV2. The mental health crises brought about by this pandemic have been highlighted in many studies. The emerging links between cancer and stress make it more important than ever before to assess the stress burden of cancer patients and expand the strategies for its management. Frontiers Media S.A. 2021-07-15 /pmc/articles/PMC8320172/ /pubmed/34336866 http://dx.doi.org/10.3389/fcell.2021.714999 Text en Copyright © 2021 Iftikhar, Islam, Shepherd, Jones and Ellis. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Iftikhar, Anem Islam, Mohammad Shepherd, Simon Jones, Sarah Ellis, Ian Is RAS the Link Between COVID-19 and Increased Stress in Head and Neck Cancer Patients? |
title | Is RAS the Link Between COVID-19 and Increased Stress in Head and Neck Cancer Patients? |
title_full | Is RAS the Link Between COVID-19 and Increased Stress in Head and Neck Cancer Patients? |
title_fullStr | Is RAS the Link Between COVID-19 and Increased Stress in Head and Neck Cancer Patients? |
title_full_unstemmed | Is RAS the Link Between COVID-19 and Increased Stress in Head and Neck Cancer Patients? |
title_short | Is RAS the Link Between COVID-19 and Increased Stress in Head and Neck Cancer Patients? |
title_sort | is ras the link between covid-19 and increased stress in head and neck cancer patients? |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8320172/ https://www.ncbi.nlm.nih.gov/pubmed/34336866 http://dx.doi.org/10.3389/fcell.2021.714999 |
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