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Statins act as transient type I interferon inhibitors to enable the antitumor activity of modified vaccinia Ankara viral vectors

BACKGROUND: Modified vaccinia virus Ankara (MVA) are genetically engineered non-replicating viral vectors. Intratumoral administration of MVA induces a cyclic GMP-AMP synthase-mediated type I interferon (IFN) response and the production of high levels of the transgenes engineered into the viral geno...

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Detalles Bibliográficos
Autores principales:	Tenesaca, Shirley, Vasquez, Marcos, Alvarez, Maite, Otano, Itziar, Fernandez-Sendin, Myriam, Di Trani, Claudia Augusta, Ardaiz, Nuria, Gomar, Celia, Bella, Angela, Aranda, Fernando, Medina-Echeverz, José, Melero, Ignacio, Berraondo, Pedro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2021
Materias:	Oncolytic and Local Immunotherapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8320251/ https://www.ncbi.nlm.nih.gov/pubmed/34321273 http://dx.doi.org/10.1136/jitc-2020-001587

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