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Direct identification of neoantigen-specific TCRs from tumor specimens by high-throughput single-cell sequencing

BACKGROUND: Recognition of neoantigens by T cells plays a major role in cancer immunotherapy. Identification of neoantigen-specific T-cell receptors (TCRs) has become a critical research tool for studying T cell-mediated responses after immunotherapy. In addition, neoantigen-specific TCRs can be use...

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Detalles Bibliográficos
Autores principales:	Lu, Yong-Chen, Zheng, Zhili, Lowery, Frank J, Gartner, Jared J, Prickett, Todd D, Robbins, Paul F, Rosenberg, Steven A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2021
Materias:	Immune Cell Therapies and Immune Cell Engineering
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8320258/ https://www.ncbi.nlm.nih.gov/pubmed/34321276 http://dx.doi.org/10.1136/jitc-2021-002595

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