Broadly neutralizing antibodies and vaccine design against HIV-1 infection

Remarkable progress has been achieved for prophylactic and therapeutic interventions against human immunodeficiency virus type I (HIV-1) through antiretroviral therapy. However, vaccine development has remained challenging. Recent discoveries in broadly neutralizing monoclonal antibodies (bNAbs) has...

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Detalles Bibliográficos
Autores principales: Wang, Qian, Zhang, Linqi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Higher Education Press 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8320319/
https://www.ncbi.nlm.nih.gov/pubmed/31858368
http://dx.doi.org/10.1007/s11684-019-0721-9
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author Wang, Qian
Zhang, Linqi
author_facet Wang, Qian
Zhang, Linqi
author_sort Wang, Qian
collection PubMed
description Remarkable progress has been achieved for prophylactic and therapeutic interventions against human immunodeficiency virus type I (HIV-1) through antiretroviral therapy. However, vaccine development has remained challenging. Recent discoveries in broadly neutralizing monoclonal antibodies (bNAbs) has led to the development of multiple novel vaccine approaches for inducing bNAbs-like antibody response. Structural and dynamic studies revealed several vulnerable sites and states of the HIV-1 envelop glycoprotein (Env) during infection. Our review aims to highlight these discoveries and rejuvenate our endeavor in HIV-1 vaccine design and development.
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spelling pubmed-83203192021-07-29 Broadly neutralizing antibodies and vaccine design against HIV-1 infection Wang, Qian Zhang, Linqi Front Med Review Remarkable progress has been achieved for prophylactic and therapeutic interventions against human immunodeficiency virus type I (HIV-1) through antiretroviral therapy. However, vaccine development has remained challenging. Recent discoveries in broadly neutralizing monoclonal antibodies (bNAbs) has led to the development of multiple novel vaccine approaches for inducing bNAbs-like antibody response. Structural and dynamic studies revealed several vulnerable sites and states of the HIV-1 envelop glycoprotein (Env) during infection. Our review aims to highlight these discoveries and rejuvenate our endeavor in HIV-1 vaccine design and development. Higher Education Press 2019-12-19 2020 /pmc/articles/PMC8320319/ /pubmed/31858368 http://dx.doi.org/10.1007/s11684-019-0721-9 Text en © The Author(s) 2019 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Review
Wang, Qian
Zhang, Linqi
Broadly neutralizing antibodies and vaccine design against HIV-1 infection
title Broadly neutralizing antibodies and vaccine design against HIV-1 infection
title_full Broadly neutralizing antibodies and vaccine design against HIV-1 infection
title_fullStr Broadly neutralizing antibodies and vaccine design against HIV-1 infection
title_full_unstemmed Broadly neutralizing antibodies and vaccine design against HIV-1 infection
title_short Broadly neutralizing antibodies and vaccine design against HIV-1 infection
title_sort broadly neutralizing antibodies and vaccine design against hiv-1 infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8320319/
https://www.ncbi.nlm.nih.gov/pubmed/31858368
http://dx.doi.org/10.1007/s11684-019-0721-9
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