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Atorvastatin Plus Low-Dose Dexamethasone May Be Effective for Leukemia-Related Chronic Subdural Hematoma but Not for Leukemia Encephalopathy: A Report of Three Cases

We are not aware of any reports regarding conservative treatment for leukemia-related chronic subdural hematoma (CSDH). We report our experience with 3 men who were admitted with subdural masses and abnormal leukocyte counts. In two patients, leukemia and CSDH were confirmed on the basis of medical...

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Autores principales: Yuan, Jiangyuan, Li, Ying, Liu, Xuanhui, Nie, Meng, Jiang, Weiwei, Fan, Yibing, Xiang, Tangtang, Wang, Hanhua, Quan, Wei, Gao, Chuang, Huang, Jinghao, An, Shuo, Ru, Yongxin, Zhou, Qiufan, Zhang, Jianning, Jiang, Rongcai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8320332/
https://www.ncbi.nlm.nih.gov/pubmed/34336644
http://dx.doi.org/10.3389/fonc.2021.628927
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author Yuan, Jiangyuan
Li, Ying
Liu, Xuanhui
Nie, Meng
Jiang, Weiwei
Fan, Yibing
Xiang, Tangtang
Wang, Hanhua
Quan, Wei
Gao, Chuang
Huang, Jinghao
An, Shuo
Ru, Yongxin
Zhou, Qiufan
Zhang, Jianning
Jiang, Rongcai
author_facet Yuan, Jiangyuan
Li, Ying
Liu, Xuanhui
Nie, Meng
Jiang, Weiwei
Fan, Yibing
Xiang, Tangtang
Wang, Hanhua
Quan, Wei
Gao, Chuang
Huang, Jinghao
An, Shuo
Ru, Yongxin
Zhou, Qiufan
Zhang, Jianning
Jiang, Rongcai
author_sort Yuan, Jiangyuan
collection PubMed
description We are not aware of any reports regarding conservative treatment for leukemia-related chronic subdural hematoma (CSDH). We report our experience with 3 men who were admitted with subdural masses and abnormal leukocyte counts. In two patients, leukemia and CSDH were confirmed on the basis of medical records, mild head trauma, and neuroimaging features. Both patients experienced reduced CSDH and neurological symptoms after receiving atorvastatin (20 mg/day) plus low-dose dexamethasone. However, this combined conservative treatment was ineffective in the third patient, who was diagnosed as having leukemia and showed an increased hematoma volume after two weeks of therapy. Magnetic resonance imaging findings suggested dural metastasis, which prompted a switch from statin-based conservative treatment to chemotherapy. Complete remission of the leukemia and resolution of the subdural mass were observed after chemotherapy, which supported a diagnosis of leukemia encephalopathy. The 5-month follow-ups did not reveal CSDH relapse in all 3 cases. Thus, atorvastatin-based conservative treatment may be effective for leukemia-related CSDH but not for leukemia encephalopathy.
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spelling pubmed-83203322021-07-30 Atorvastatin Plus Low-Dose Dexamethasone May Be Effective for Leukemia-Related Chronic Subdural Hematoma but Not for Leukemia Encephalopathy: A Report of Three Cases Yuan, Jiangyuan Li, Ying Liu, Xuanhui Nie, Meng Jiang, Weiwei Fan, Yibing Xiang, Tangtang Wang, Hanhua Quan, Wei Gao, Chuang Huang, Jinghao An, Shuo Ru, Yongxin Zhou, Qiufan Zhang, Jianning Jiang, Rongcai Front Oncol Oncology We are not aware of any reports regarding conservative treatment for leukemia-related chronic subdural hematoma (CSDH). We report our experience with 3 men who were admitted with subdural masses and abnormal leukocyte counts. In two patients, leukemia and CSDH were confirmed on the basis of medical records, mild head trauma, and neuroimaging features. Both patients experienced reduced CSDH and neurological symptoms after receiving atorvastatin (20 mg/day) plus low-dose dexamethasone. However, this combined conservative treatment was ineffective in the third patient, who was diagnosed as having leukemia and showed an increased hematoma volume after two weeks of therapy. Magnetic resonance imaging findings suggested dural metastasis, which prompted a switch from statin-based conservative treatment to chemotherapy. Complete remission of the leukemia and resolution of the subdural mass were observed after chemotherapy, which supported a diagnosis of leukemia encephalopathy. The 5-month follow-ups did not reveal CSDH relapse in all 3 cases. Thus, atorvastatin-based conservative treatment may be effective for leukemia-related CSDH but not for leukemia encephalopathy. Frontiers Media S.A. 2021-07-15 /pmc/articles/PMC8320332/ /pubmed/34336644 http://dx.doi.org/10.3389/fonc.2021.628927 Text en Copyright © 2021 Yuan, Li, Liu, Nie, Jiang, Fan, Xiang, Wang, Quan, Gao, Huang, An, Ru, Zhou, Zhang and Jiang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Yuan, Jiangyuan
Li, Ying
Liu, Xuanhui
Nie, Meng
Jiang, Weiwei
Fan, Yibing
Xiang, Tangtang
Wang, Hanhua
Quan, Wei
Gao, Chuang
Huang, Jinghao
An, Shuo
Ru, Yongxin
Zhou, Qiufan
Zhang, Jianning
Jiang, Rongcai
Atorvastatin Plus Low-Dose Dexamethasone May Be Effective for Leukemia-Related Chronic Subdural Hematoma but Not for Leukemia Encephalopathy: A Report of Three Cases
title Atorvastatin Plus Low-Dose Dexamethasone May Be Effective for Leukemia-Related Chronic Subdural Hematoma but Not for Leukemia Encephalopathy: A Report of Three Cases
title_full Atorvastatin Plus Low-Dose Dexamethasone May Be Effective for Leukemia-Related Chronic Subdural Hematoma but Not for Leukemia Encephalopathy: A Report of Three Cases
title_fullStr Atorvastatin Plus Low-Dose Dexamethasone May Be Effective for Leukemia-Related Chronic Subdural Hematoma but Not for Leukemia Encephalopathy: A Report of Three Cases
title_full_unstemmed Atorvastatin Plus Low-Dose Dexamethasone May Be Effective for Leukemia-Related Chronic Subdural Hematoma but Not for Leukemia Encephalopathy: A Report of Three Cases
title_short Atorvastatin Plus Low-Dose Dexamethasone May Be Effective for Leukemia-Related Chronic Subdural Hematoma but Not for Leukemia Encephalopathy: A Report of Three Cases
title_sort atorvastatin plus low-dose dexamethasone may be effective for leukemia-related chronic subdural hematoma but not for leukemia encephalopathy: a report of three cases
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8320332/
https://www.ncbi.nlm.nih.gov/pubmed/34336644
http://dx.doi.org/10.3389/fonc.2021.628927
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