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Discovery of a New CDK4/6 and PI3K/AKT Multiple Kinase Inhibitor Aminoquinol for the Treatment of Hepatocellular Carcinoma

Background: Hepatocellular carcinoma (HCC) is a lethal malignancy lacking effective treatment. The Cyclin-dependent kinases 4/6 (CDK4/6) and PI3K/AKT signal pathways play pivotal roles in carcinogenesis and are promising therapeutic targets for HCC. Here we identified a new CDK4/6 and PI3K/AKT multi...

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Detalles Bibliográficos
Autores principales:	Xia, Zhong-Kun, Wang, Wei, Qiu, Jian-Ge, Shi, Xi-Nan, Li, Hong-Jian, Chen, Rong, Ke, Kun-Bin, Dong, Chao, Zhu, Ying, Wu, Shi-Guo, Zhang, Rong-Ping, Meng, Zhuo-Ran, Zhao, Hui, Gu, Peng, Leung, Kwong-Sak, Wong, Man-Hon, Liu, Xiao-Dong, Zhou, Feng-Mei, Zhang, Jian-Ying, Yao, Ya-Ting, Wang, Si-Jia, Zhang, Chun-Yang, Qin, Yan-Ru, Lin, Marie Chia-mi, Jiang, Bing-Hua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8320333/ https://www.ncbi.nlm.nih.gov/pubmed/34335258 http://dx.doi.org/10.3389/fphar.2021.691769

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