Cargando…

Comparison of the basic morphology and function of 3D lung epithelial cultures derived from several donors

In vitro models of the human lung play an essential role in evaluating the toxicity of inhaled compounds and understanding the development of respiratory diseases. Three-dimensional (3D) organotypic models derived from lung basal epithelial cells and grown at the air–liquid interface resemble human...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bovard, David, Giralt, Albert, Trivedi, Keyur, Neau, Laurent, Kanellos, Petros, Iskandar, Anita, Kondylis, Athanasios, Luettich, Karsta, Frentzel, Stefan, Hoeng, Julia, Peitsch, Manuel C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8320645/ https://www.ncbi.nlm.nih.gov/pubmed/34345837 http://dx.doi.org/10.1016/j.crtox.2020.08.002

Ejemplares similares

Effects of cigarette smoke exposure on a mouse model of multiple sclerosis
por: Ho, Jenny, et al.
Publicado: (2022)

Human multi-organ chip co-culture of bronchial lung culture and liver spheroids for substance exposure studies
por: Schimek, Katharina, et al.
Publicado: (2020)

Discriminating Spontaneous From Cigarette Smoke and THS 2.2 Aerosol Exposure-Related Proliferative Lung Lesions in A/J Mice by Using Gene Expression and Mutation Spectrum Data
por: Xiang, Yang, et al.
Publicado: (2021)

Systems toxicology approaches enable mechanistic comparison of spontaneous and cigarette smoke-related lung tumor development in the A/J mouse model
por: Luettich, Karsta, et al.
Publicado: (2014)

Development of an Advanced Multicellular Intestinal Model for Assessing Immunomodulatory Properties of Anti-Inflammatory Compounds
por: Marescotti, Diego, et al.
Publicado: (2021)

Organ on a chip: engineered microenvironments for safety and efficacy testing
por: Hoeng, Julia, et al.
Publicado: (2019)

A lower impact of an acute exposure to electronic cigarette aerosols than to cigarette smoke in human organotypic buccal and small airway cultures was demonstrated using systems toxicology assessment
por: Iskandar, Anita R., et al.
Publicado: (2019)

Construction of a Suite of Computable Biological Network Models Focused on Mucociliary Clearance in the Respiratory Tract
por: Yepiskoposyan, Hasmik, et al.
Publicado: (2019)

Alterations in Serum Polyunsaturated Fatty Acids and Eicosanoids in Patients with Mild to Moderate Chronic Obstructive Pulmonary Disease (COPD)
por: Titz, Bjoern, et al.
Publicado: (2016)

Physiological and biological characterization of smokers with and without COPD
por: Chaudhary, Nveed, et al.
Publicado: (2018)

Mechanistic Evaluation of the Impact of Smoking and Chronic Obstructive Pulmonary Disease on the Nasal Epithelium
por: Talikka, Marja, et al.
Publicado: (2017)

Respiratory Effects of Exposure to Aerosol From the Candidate Modified-Risk Tobacco Product THS 2.2 in an 18-Month Systems Toxicology Study With A/J Mice
por: Titz, Bjoern, et al.
Publicado: (2020)

Impact Assessment of Cigarette Smoke Exposure on Organotypic Bronchial Epithelial Tissue Cultures: A Comparison of Mono-Culture and Coculture Model Containing Fibroblasts
por: Iskandar, Anita R., et al.
Publicado: (2015)

Comparative effects of a candidate modified-risk tobacco product Aerosol and cigarette smoke on human organotypic small airway cultures: a systems toxicology approach
por: Iskandar, Anita R., et al.
Publicado: (2017)

In vitro systems toxicology approach to investigate the effects of repeated cigarette smoke exposure on human buccal and gingival organotypic epithelial tissue cultures
por: Schlage, Walter K., et al.
Publicado: (2014)

Retraction: TGFβ(1 )activates c-Jun and Erk1 via a(V)β(6 )integrin
por: Luettich, Karsta, et al.
Publicado: (2004)

TGFβ(1 )activates c-Jun and Erk1 via α(V)β(6 )integrin
por: Luettich, Karsta, et al.
Publicado: (2003)

Reduced Chronic Toxicity and Carcinogenicity in A/J Mice in Response to Life-Time Exposure to Aerosol From a Heated Tobacco Product Compared With Cigarette Smoke
por: Wong, Ee Tsin, et al.
Publicado: (2020)

High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents (HPHC)
por: Marescotti, Diego, et al.
Publicado: (2016)

Lung cancer biomarkers for the assessment of modified risk tobacco products: an oxidative stress perspective
por: Lowe, Frazer J., et al.
Publicado: (2013)

Iota-carrageenan extracted from red algae is a potent inhibitor of SARS‐CoV-2 infection in reconstituted human airway epithelia
por: Bovard, David, et al.
Publicado: (2021)

Impact Assessment of Repeated Exposure of Organotypic 3D Bronchial and Nasal Tissue Culture Models to Whole Cigarette Smoke
por: Kuehn, Diana, et al.
Publicado: (2015)

Mitochondria as a possible target for nicotine action
por: Malińska, Dominika, et al.
Publicado: (2019)

First anniversary of Molecular Cancer: achievements and future goals
por: Deora, Arun B, et al.
Publicado: (2003)

A meta-analysis of microRNAs expressed in human aerodigestive epithelial cultures and their role as potential biomarkers of exposure response to nicotine-containing products
por: Sewer, Alain, et al.
Publicado: (2020)

An Adverse Outcome Pathway for Decreased Lung Function Focusing on Mechanisms of Impaired Mucociliary Clearance Following Inhalation Exposure
por: Luettich, Karsta, et al.
Publicado: (2021)

Systems toxicology meta-analysis of in vitro assessment studies: biological impact of a candidate modified-risk tobacco product aerosol compared with cigarette smoke on human organotypic cultures of the aerodigestive tract
por: Iskandar, A. R., et al.
Publicado: (2017)

Pulmonary Delivery of Aerosolized Chloroquine and Hydroxychloroquine to Treat COVID-19: In Vitro Experimentation to Human Dosing Predictions
por: Kolli, Aditya R., et al.
Publicado: (2022)

Characterization of the Vitrocell® 24/48 in vitro aerosol exposure system using mainstream cigarette smoke
por: Majeed, Shoaib, et al.
Publicado: (2014)

Systems Approaches Evaluating the Perturbation of Xenobiotic Metabolism in Response to Cigarette Smoke Exposure in Nasal and Bronchial Tissues
por: Iskandar, Anita R., et al.
Publicado: (2013)

A framework for in vitro systems toxicology assessment of e-liquids
por: Iskandar, Anita R., et al.
Publicado: (2016)

Differentiating the Neuropharmacological Properties of Nicotinic Acetylcholine Receptor-Activating Alkaloids
por: Alijevic, Omar, et al.
Publicado: (2022)

Systems Toxicology: From Basic Research to Risk Assessment
por: Sturla, Shana J., et al.
Publicado: (2014)

Apical Medium Flow Influences the Morphology and Physiology of Human Proximal Tubular Cells in a Microphysiological System
por: Specioso, Gabriele, et al.
Publicado: (2022)

Assessment of inhalation toxicity of cigarette smoke and aerosols from flavor mixtures: 5‐week study in A/J mice
por: Wong, Ee Tsin, et al.
Publicado: (2022)

Construction of biological networks from unstructured information based on a semi-automated curation workflow
por: Szostak, Justyna, et al.
Publicado: (2015)

Effects of nicotinic acetylcholine receptor-activating alkaloids on anxiety-like behavior in zebrafish
por: Alzualde, Ainhoa, et al.
Publicado: (2021)

Impact of sample preparation upon intracellular metabolite measurements in 3D cell culture systems
por: Mathon, Caroline, et al.
Publicado: (2019)

Internal carotid artery origin of the anterior cerebral artery: A rare anatomic intracranial arterial variation in a child with morning glory disc anomaly and moyamoya vascular pattern; case report and review of literature
por: Solomou, Aikaterini, et al.
Publicado: (2020)

Assessing the lung cancer risk reduction potential of candidate modified risk tobacco products
por: Hoeng, Julia, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_l8169plr6uo93895ds0581d2li