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Gout Augments the Risk of Cardiovascular Disease in Patients With Psoriasis: A Population-Based Cohort Study

OBJECTIVE: Patients with psoriasis (PsO) have a high frequency of concomitant gout and increased risk of cardiovascular diseases (CVD). We aimed to estimate the synergistic impact of gout on the risk of CVD in patients with PsO. METHODS: A population-based cohort of patients registered in the Nation...

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Autores principales: Chen, Zhiyong, Xu, Yiwen, Chen, Miao, Cui, Ran, Wang, Yu-Hsun, Dai, Sheng-Ming, Wei, James Cheng-Chung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8320695/
https://www.ncbi.nlm.nih.gov/pubmed/34335617
http://dx.doi.org/10.3389/fimmu.2021.703119
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author Chen, Zhiyong
Xu, Yiwen
Chen, Miao
Cui, Ran
Wang, Yu-Hsun
Dai, Sheng-Ming
Wei, James Cheng-Chung
author_facet Chen, Zhiyong
Xu, Yiwen
Chen, Miao
Cui, Ran
Wang, Yu-Hsun
Dai, Sheng-Ming
Wei, James Cheng-Chung
author_sort Chen, Zhiyong
collection PubMed
description OBJECTIVE: Patients with psoriasis (PsO) have a high frequency of concomitant gout and increased risk of cardiovascular diseases (CVD). We aimed to estimate the synergistic impact of gout on the risk of CVD in patients with PsO. METHODS: A population-based cohort of patients registered in the National Health Insurance Research Database of Taiwan between 2000 and 2013 was stratified according to the presence of PsO and gout. Propensity score analysis was used to match age and gender at a ratio of 1:4. Cox proportional hazard models and subgroup analyses were used to estimate the hazard ratios (HRs) for CVD adjusted for traditional risk factors. The Kaplan–Meier method was used to plot the cumulative incidence curves. RESULTS: Patients with combined PsO and gout (n = 97), PsO alone (n = 388), gout alone (matched, n = 388) and matched controls (n = 388) were identified. Compared with the patients with PsO alone, the patients with combined PsO and gout had a significantly higher risk of CVD (relative risk 2.39, 95% CI 1.56 to 3.65). After adjustment for traditional risk factors, the risk of CVD was higher in patients with gout alone (HR 2.16, 95% CI 1.54 to 3.04) and in patients with combined PsO and gout (HR 2.72, 95% CI 1.73 to 4.28). CONCLUSIONS: Gout augments the risk of CVD independently of traditional risk factors in patients with PsO.
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spelling pubmed-83206952021-07-30 Gout Augments the Risk of Cardiovascular Disease in Patients With Psoriasis: A Population-Based Cohort Study Chen, Zhiyong Xu, Yiwen Chen, Miao Cui, Ran Wang, Yu-Hsun Dai, Sheng-Ming Wei, James Cheng-Chung Front Immunol Immunology OBJECTIVE: Patients with psoriasis (PsO) have a high frequency of concomitant gout and increased risk of cardiovascular diseases (CVD). We aimed to estimate the synergistic impact of gout on the risk of CVD in patients with PsO. METHODS: A population-based cohort of patients registered in the National Health Insurance Research Database of Taiwan between 2000 and 2013 was stratified according to the presence of PsO and gout. Propensity score analysis was used to match age and gender at a ratio of 1:4. Cox proportional hazard models and subgroup analyses were used to estimate the hazard ratios (HRs) for CVD adjusted for traditional risk factors. The Kaplan–Meier method was used to plot the cumulative incidence curves. RESULTS: Patients with combined PsO and gout (n = 97), PsO alone (n = 388), gout alone (matched, n = 388) and matched controls (n = 388) were identified. Compared with the patients with PsO alone, the patients with combined PsO and gout had a significantly higher risk of CVD (relative risk 2.39, 95% CI 1.56 to 3.65). After adjustment for traditional risk factors, the risk of CVD was higher in patients with gout alone (HR 2.16, 95% CI 1.54 to 3.04) and in patients with combined PsO and gout (HR 2.72, 95% CI 1.73 to 4.28). CONCLUSIONS: Gout augments the risk of CVD independently of traditional risk factors in patients with PsO. Frontiers Media S.A. 2021-07-15 /pmc/articles/PMC8320695/ /pubmed/34335617 http://dx.doi.org/10.3389/fimmu.2021.703119 Text en Copyright © 2021 Chen, Xu, Chen, Cui, Wang, Dai and Wei https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Chen, Zhiyong
Xu, Yiwen
Chen, Miao
Cui, Ran
Wang, Yu-Hsun
Dai, Sheng-Ming
Wei, James Cheng-Chung
Gout Augments the Risk of Cardiovascular Disease in Patients With Psoriasis: A Population-Based Cohort Study
title Gout Augments the Risk of Cardiovascular Disease in Patients With Psoriasis: A Population-Based Cohort Study
title_full Gout Augments the Risk of Cardiovascular Disease in Patients With Psoriasis: A Population-Based Cohort Study
title_fullStr Gout Augments the Risk of Cardiovascular Disease in Patients With Psoriasis: A Population-Based Cohort Study
title_full_unstemmed Gout Augments the Risk of Cardiovascular Disease in Patients With Psoriasis: A Population-Based Cohort Study
title_short Gout Augments the Risk of Cardiovascular Disease in Patients With Psoriasis: A Population-Based Cohort Study
title_sort gout augments the risk of cardiovascular disease in patients with psoriasis: a population-based cohort study
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8320695/
https://www.ncbi.nlm.nih.gov/pubmed/34335617
http://dx.doi.org/10.3389/fimmu.2021.703119
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