Cargando…

Reversing Epigenetic Gene Silencing to Overcome Immune Evasion in CNS Malignancies

Glioblastoma (GBM) is an aggressive brain malignancy with a dismal prognosis. With emerging evidence to disprove brain-immune privilege, there has been much interest in examining immunotherapy strategies to treat central nervous system (CNS) cancers. Unfortunately, the limited success of clinical st...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ratnam, Nivedita M., Sonnemann, Heather M., Frederico, Stephen C., Chen, Huanwen, Hutchinson, Marsha-Kay N. D., Dowdy, Tyrone, Reid, Caitlin M., Jung, Jinkyu, Zhang, Wei, Song, Hua, Zhang, Meili, Davis, Dionne, Larion, Mioara, Giles, Amber J., Gilbert, Mark R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8320893/ https://www.ncbi.nlm.nih.gov/pubmed/34336705 http://dx.doi.org/10.3389/fonc.2021.719091

Ejemplares similares

Targeting the Sphingolipid Rheostat in Gliomas
por: Zaibaq, Faris, et al.
Publicado: (2022)

Dexamethasone-induced immunosuppression: mechanisms and implications for immunotherapy
por: Giles, Amber J., et al.
Publicado: (2018)

DDRE-16. CYSTEINE IS AN ESSENTIAL AMINO ACID IN GLIOMAS
por: Ruiz-Rodado, Victor, et al.
Publicado: (2021)

Cysteine is a limiting factor for glioma proliferation and survival
por: Ruiz‐Rodado, Victor, et al.
Publicado: (2022)

Detection of Metabolic Changes Induced via Drug Treatments in Live Cancer Cells and Tissue Using Raman Imaging Microscopy
por: Larion, Mioara, et al.
Publicado: (2018)

Metabolic Landscape of a Genetically Engineered Mouse Model of IDH1 Mutant Glioma
por: Ruiz-Rodado, Victor, et al.
Publicado: (2020)

BIMG-10. IDH1 MUTATIONS INDUCE ORGANELLE DEFECTS VIA DYSREGULATED PHOSPHOLIPIDS
por: Yamasaki, Tomohiro, et al.
Publicado: (2021)

DDRE-20. TARGETING SPHINGOLIPID PATHWAY REVEALS VULNERABILITY IN IDH1(MUT) GLIOMA
por: Dowdy, Tyrone, et al.
Publicado: (2021)

OTME-4. IDH mutated gliomas promote epileptogenesis via D-2-hydroxyglutarate dependent mTOR hyperactivation
por: Mortazavi, Armin, et al.
Publicado: (2021)

Magnetic resonance spectroscopy for the study of cns malignancies
por: Ruiz-Rodado, Victor, et al.
Publicado: (2020)

Metabolic biomarkers of radiotherapy response in plasma and tissue of an IDH1 mutant astrocytoma mouse model
por: Ruiz-Rodado, Victor, et al.
Publicado: (2022)

Sphingolipid Pathway as a Source of Vulnerability in IDH1(mut) Glioma
por: Dowdy, Tyrone, et al.
Publicado: (2020)

CBMS-5 STEAROYL-COA DESATURASE INHIBITOR INDUCES APOPTOSIS VIA ENHANCING LIPOLYSIS IN IDH MUTANT GLIOMA
por: Zhang, Lumin, et al.
Publicado: (2022)

DDRE-27. IDH MUTATED GLIOMAS PROMOTE EPILEPTOGENESIS VIA D-2-HYDROXYGLUTARATE DEPENDENT MTOR HYPERACTIVATION
por: Mortazavi, Armin, et al.
Publicado: (2021)

Overcoming Immune Evasion in Melanoma
por: Eddy, Kevinn, et al.
Publicado: (2020)

Overcoming tumor immune evasion with an unique arbovirus
por: Lyday, Bruce, et al.
Publicado: (2015)

Metabolic plasticity of IDH1-mutant glioma cell lines is responsible for low sensitivity to glutaminase inhibition
por: Ruiz-Rodado, Victor, et al.
Publicado: (2020)

MAG, myelin and overcoming growth inhibition in the CNS
por: McKerracher, Lisa, et al.
Publicado: (2015)

DDRE-01. METABOLIC PLASTICITY AND HETEROGENEITY IN IDH1MUT CELL LINES PRODUCES RESISTANCE TO GLUTAMINASE INHIBITION BY CB839
por: Larion, Mioara, et al.
Publicado: (2021)

Triple Immunotherapy Overcomes Immune Evasion by Tumor in a Melanoma Mouse Model
por: Jallad, Mary-Ann N., et al.
Publicado: (2020)

Combinatorial immunotherapies overcome MYC-driven immune evasion in triple negative breast cancer
por: Lee, Joyce V., et al.
Publicado: (2022)

Extracellular Vesicles as a Means of Viral Immune Evasion, CNS Invasion, and Glia-Induced Neurodegeneration
por: Horn, Miranda D., et al.
Publicado: (2021)

Retinoid receptor turnover mediated by sumoylation, ubiquitination and the valosin-containing protein is disrupted in glioblastoma
por: Rodriguez, Virginia, et al.
Publicado: (2019)

Acoustic Aposematism and Evasive Action in Select Chemically Defended Arctiine (Lepidoptera: Erebidae) Species: Nonchalant or Not?
por: Dowdy, Nicolas J., et al.
Publicado: (2016)

Editorial: Strategies to overcome tumor evasion and resistance to immunotherapies by targeting immune suppressor cells
por: Saida, Yu, et al.
Publicado: (2023)

Author Correction: Combinatorial immunotherapies overcome MYC-driven immune evasion in triple negative breast cancer
por: Lee, Joyce V., et al.
Publicado: (2022)

The New Era of Cancer Immunotherapy: Targeting Myeloid-Derived Suppressor Cells to Overcome Immune Evasion
por: De Cicco, Paola, et al.
Publicado: (2020)

Nanotechnology-Based siRNA Delivery Systems to Overcome Tumor Immune Evasion in Cancer Immunotherapy
por: Deng, Kaili, et al.
Publicado: (2022)

Mating can initiate stable RNA silencing that overcomes epigenetic recovery
por: Devanapally, Sindhuja, et al.
Publicado: (2021)

BCAbox Algorithm Expands Capabilities of Raman Microscope for Single Organelles Assessment
por: Kuzmin, Andrey N., et al.
Publicado: (2018)

Making a Cold Tumor Hot: The Role of Vaccines in the Treatment of Glioblastoma
por: Frederico, Stephen C., et al.
Publicado: (2021)

Overcoming sorafenib evasion in hepatocellular carcinoma using CXCR4-targeted nanoparticles to co-deliver MEK-inhibitors
por: Chen, Yunching, et al.
Publicado: (2017)

DDRE-08. NRF2/GLUTATHIONE METABOLISM AS A NOVEL THERAPEUTIC TARGET FOR IDH1-MUTATED GLIOMA
por: Liu, Yang, et al.
Publicado: (2021)

Probabilistic model checking of cancer metabolism
por: Friedenberg, Meir D., et al.
Publicado: (2022)

Global CNS Gene Delivery and Evasion of Anti-AAV Neutralizing Antibodies by Intrathecal AAV Administration in Non-Human Primates
por: Gray, Steven J., et al.
Publicado: (2013)

Silencing of circCRIM1 Drives IGF2BP1-Mediated NSCLC Immune Evasion
por: Peng, Wenbei, et al.
Publicado: (2023)

Time for change: Overcoming perpetual feelings of inadequacy and silenced struggles in medicine
por: Atherley, Anique, et al.
Publicado: (2019)

Order–Disorder Transitions Govern Kinetic Cooperativity and Allostery of Monomeric Human Glucokinase
por: Larion, Mioara, et al.
Publicado: (2012)

Evasión /
por: Dardick, Matilde
Publicado: (1978)

Intranasal Peptide Therapeutics: A Promising Avenue for Overcoming the Challenges of Traditional CNS Drug Development
por: Bose, Meenakshi, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_f9vpv3306nv6r0k5f2ucroif41