Comparison of the SARS-CoV-2 spike protein ELISA and the Abbott Architect SARS-CoV-2 IgG nucleocapsid protein assays for detection of antibodies

Serologic assays developed for SARS-CoV-2 detect different antibody subtypes and are based on different target antigens. Comparison of the performance of a SARS-CoV-2 Spike-Protein ELISA and the nucleocapsid-based Abbott Architect(TM) SARS-CoV-2 IgG assay indicated that the assays had high concordan...

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Detalles Bibliográficos
Autores principales: Wadhwa, Ashutosh, Yin, Sherry, Freeman, Brandi, Hershow, Rebecca B., Killerby, Marie, Yousaf, Anna R., Lester, Sandra, Mills, Lisa, Buono, Sean A., Pomeroy, Mary, Owusu, Daniel, Chu, Victoria T., Tate, Jacqueline E., Bhattacharyya, Sanjib, Hall, Patricia, Thornburg, Natalie J., Kirking, Hannah L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8320896/
https://www.ncbi.nlm.nih.gov/pubmed/34324576
http://dx.doi.org/10.1371/journal.pone.0255208
Descripción
Sumario:Serologic assays developed for SARS-CoV-2 detect different antibody subtypes and are based on different target antigens. Comparison of the performance of a SARS-CoV-2 Spike-Protein ELISA and the nucleocapsid-based Abbott Architect(TM) SARS-CoV-2 IgG assay indicated that the assays had high concordance, with rare paired discordant tests results.

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