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Long-term effects of coronavirus disease 2019 on the cardiovascular system, CV COVID registry: A structured summary of a study protocol

BACKGROUND: Patients presenting with the coronavirus-2019 disease (COVID-19) may have a high risk of cardiovascular adverse events, including death from cardiovascular causes. The long-term cardiovascular outcomes of these patients are entirely unknown. We aim to perform a registry of patients who h...

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Detalles Bibliográficos
Autores principales: Arévalos, Victor, Ortega-Paz, Luis, Fernandez-Rodríguez, Diego, Alfonso Jiménez-Díaz, Víctor, Rius, Jordi Bañeras, Campo, Gianluca, Rodríguez-Santamarta, Miguel, de Prado, Armando Pérez, Gómez-Menchero, Antonio, Díaz Fernández, José Francisco, Scardino, Claudia, Gonzalo, Nieves, Pernigotti, Alberto, Alfonso, Fernando, Jesús Amat-Santos, Ignacio, Silvestro, Antonio, Ielasi, Alfonso, María de la Torre, José, Bastidas, Gabriela, Gómez-Lara, Josep, Sabaté, Manel, Brugaletta, Salvatore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8320971/
https://www.ncbi.nlm.nih.gov/pubmed/34324524
http://dx.doi.org/10.1371/journal.pone.0255263
Descripción
Sumario:BACKGROUND: Patients presenting with the coronavirus-2019 disease (COVID-19) may have a high risk of cardiovascular adverse events, including death from cardiovascular causes. The long-term cardiovascular outcomes of these patients are entirely unknown. We aim to perform a registry of patients who have undergone a diagnostic nasopharyngeal swab for SARS-CoV-2 and to determine their long-term cardiovascular outcomes. STUDY AND DESIGN: This is a multicenter, observational, retrospective registry to be conducted at 17 centers in Spain and Italy (ClinicalTrials.gov number: NCT04359927). Consecutive patients older than 18 years, who underwent a real-time reverse transcriptase-polymerase chain reaction (RT-PCR) for SARS-CoV2 in the participating institutions, will be included since March 2020, to August 2020. Patients will be classified into two groups, according to the results of the RT-PCR: COVID-19 positive or negative. The primary outcome will be cardiovascular mortality at 1 year. The secondary outcomes will be acute myocardial infarction, stroke, heart failure hospitalization, pulmonary embolism, and serious cardiac arrhythmias, at 1 year. Outcomes will be compared between the two groups. Events will be adjudicated by an independent clinical event committee. CONCLUSION: The results of this registry will contribute to a better understanding of the long-term cardiovascular implications of the COVID19.