Environmental Enrichment and Its Benefits for Migraine: Dendritic Cell Extracellular Vesicles as an Effective Mimetic

Environmental enrichment produces beneficial effects in the brain at genetic, molecular, cellular and behavior levels, and has long been studied as a therapeutic intervention for a wide variety of neurological disorders. However, the complexity of applying a robust environmental enrichment paradigm...

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Autores principales: Pusic, Kae Myriam, Won, Lisa, Kraig, Richard Paul, Pusic, Aya Darinka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321388/
https://www.ncbi.nlm.nih.gov/pubmed/34337600
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author Pusic, Kae Myriam
Won, Lisa
Kraig, Richard Paul
Pusic, Aya Darinka
author_facet Pusic, Kae Myriam
Won, Lisa
Kraig, Richard Paul
Pusic, Aya Darinka
author_sort Pusic, Kae Myriam
collection PubMed
description Environmental enrichment produces beneficial effects in the brain at genetic, molecular, cellular and behavior levels, and has long been studied as a therapeutic intervention for a wide variety of neurological disorders. However, the complexity of applying a robust environmental enrichment paradigm makes clinical use difficult. Accordingly, there has been increased interest in developing environmental enrichment mimetics, also known as enviromimetics. Here we review the benefits of environmental enrichment for migraine treatment, and discuss the potential of using extracellular vesicles derived from interferon gamma-stimulated dendritic cells as an effective mimetic.
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spelling pubmed-83213882021-07-29 Environmental Enrichment and Its Benefits for Migraine: Dendritic Cell Extracellular Vesicles as an Effective Mimetic Pusic, Kae Myriam Won, Lisa Kraig, Richard Paul Pusic, Aya Darinka J Cell Immunol Article Environmental enrichment produces beneficial effects in the brain at genetic, molecular, cellular and behavior levels, and has long been studied as a therapeutic intervention for a wide variety of neurological disorders. However, the complexity of applying a robust environmental enrichment paradigm makes clinical use difficult. Accordingly, there has been increased interest in developing environmental enrichment mimetics, also known as enviromimetics. Here we review the benefits of environmental enrichment for migraine treatment, and discuss the potential of using extracellular vesicles derived from interferon gamma-stimulated dendritic cells as an effective mimetic. 2021 /pmc/articles/PMC8321388/ /pubmed/34337600 Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Pusic, Kae Myriam
Won, Lisa
Kraig, Richard Paul
Pusic, Aya Darinka
Environmental Enrichment and Its Benefits for Migraine: Dendritic Cell Extracellular Vesicles as an Effective Mimetic
title Environmental Enrichment and Its Benefits for Migraine: Dendritic Cell Extracellular Vesicles as an Effective Mimetic
title_full Environmental Enrichment and Its Benefits for Migraine: Dendritic Cell Extracellular Vesicles as an Effective Mimetic
title_fullStr Environmental Enrichment and Its Benefits for Migraine: Dendritic Cell Extracellular Vesicles as an Effective Mimetic
title_full_unstemmed Environmental Enrichment and Its Benefits for Migraine: Dendritic Cell Extracellular Vesicles as an Effective Mimetic
title_short Environmental Enrichment and Its Benefits for Migraine: Dendritic Cell Extracellular Vesicles as an Effective Mimetic
title_sort environmental enrichment and its benefits for migraine: dendritic cell extracellular vesicles as an effective mimetic
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321388/
https://www.ncbi.nlm.nih.gov/pubmed/34337600
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AT pusicayadarinka environmentalenrichmentanditsbenefitsformigrainedendriticcellextracellularvesiclesasaneffectivemimetic

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