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Disrupting cortico-cerebellar communication impairs dexterity

To control reaching, the nervous system must generate large changes in muscle activation to drive the limb toward the target, and must also make smaller adjustments for precise and accurate behavior. Motor cortex controls the arm through projections to diverse targets across the central nervous syst...

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Autores principales: Guo, Jian-Zhong, Sauerbrei, Britton A, Cohen, Jeremy D, Mischiati, Matteo, Graves, Austin R, Pisanello, Ferruccio, Branson, Kristin M, Hantman, Adam W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321550/
https://www.ncbi.nlm.nih.gov/pubmed/34324417
http://dx.doi.org/10.7554/eLife.65906
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author Guo, Jian-Zhong
Sauerbrei, Britton A
Cohen, Jeremy D
Mischiati, Matteo
Graves, Austin R
Pisanello, Ferruccio
Branson, Kristin M
Hantman, Adam W
author_facet Guo, Jian-Zhong
Sauerbrei, Britton A
Cohen, Jeremy D
Mischiati, Matteo
Graves, Austin R
Pisanello, Ferruccio
Branson, Kristin M
Hantman, Adam W
author_sort Guo, Jian-Zhong
collection PubMed
description To control reaching, the nervous system must generate large changes in muscle activation to drive the limb toward the target, and must also make smaller adjustments for precise and accurate behavior. Motor cortex controls the arm through projections to diverse targets across the central nervous system, but it has been challenging to identify the roles of cortical projections to specific targets. Here, we selectively disrupt cortico-cerebellar communication in the mouse by optogenetically stimulating the pontine nuclei in a cued reaching task. This perturbation did not typically block movement initiation, but degraded the precision, accuracy, duration, or success rate of the movement. Correspondingly, cerebellar and cortical activity during movement were largely preserved, but differences in hand velocity between control and stimulation conditions predicted from neural activity were correlated with observed velocity differences. These results suggest that while the total output of motor cortex drives reaching, the cortico-cerebellar loop makes small adjustments that contribute to the successful execution of this dexterous movement.
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spelling pubmed-83215502021-07-30 Disrupting cortico-cerebellar communication impairs dexterity Guo, Jian-Zhong Sauerbrei, Britton A Cohen, Jeremy D Mischiati, Matteo Graves, Austin R Pisanello, Ferruccio Branson, Kristin M Hantman, Adam W eLife Neuroscience To control reaching, the nervous system must generate large changes in muscle activation to drive the limb toward the target, and must also make smaller adjustments for precise and accurate behavior. Motor cortex controls the arm through projections to diverse targets across the central nervous system, but it has been challenging to identify the roles of cortical projections to specific targets. Here, we selectively disrupt cortico-cerebellar communication in the mouse by optogenetically stimulating the pontine nuclei in a cued reaching task. This perturbation did not typically block movement initiation, but degraded the precision, accuracy, duration, or success rate of the movement. Correspondingly, cerebellar and cortical activity during movement were largely preserved, but differences in hand velocity between control and stimulation conditions predicted from neural activity were correlated with observed velocity differences. These results suggest that while the total output of motor cortex drives reaching, the cortico-cerebellar loop makes small adjustments that contribute to the successful execution of this dexterous movement. eLife Sciences Publications, Ltd 2021-07-29 /pmc/articles/PMC8321550/ /pubmed/34324417 http://dx.doi.org/10.7554/eLife.65906 Text en © 2021, Guo et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Guo, Jian-Zhong
Sauerbrei, Britton A
Cohen, Jeremy D
Mischiati, Matteo
Graves, Austin R
Pisanello, Ferruccio
Branson, Kristin M
Hantman, Adam W
Disrupting cortico-cerebellar communication impairs dexterity
title Disrupting cortico-cerebellar communication impairs dexterity
title_full Disrupting cortico-cerebellar communication impairs dexterity
title_fullStr Disrupting cortico-cerebellar communication impairs dexterity
title_full_unstemmed Disrupting cortico-cerebellar communication impairs dexterity
title_short Disrupting cortico-cerebellar communication impairs dexterity
title_sort disrupting cortico-cerebellar communication impairs dexterity
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321550/
https://www.ncbi.nlm.nih.gov/pubmed/34324417
http://dx.doi.org/10.7554/eLife.65906
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