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Distinct forms of synaptic plasticity during ascending vs descending control of medial olivocochlear efferent neurons
Activity in each brain region is shaped by the convergence of ascending and descending axonal pathways, and the balance and characteristics of these determine the neural output. The medial olivocochlear (MOC) efferent system is part of a reflex arc that critically controls auditory sensitivity. Mult...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321555/ https://www.ncbi.nlm.nih.gov/pubmed/34250904 http://dx.doi.org/10.7554/eLife.66396 |
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author | Romero, Gabriel E Trussell, Laurence O |
author_facet | Romero, Gabriel E Trussell, Laurence O |
author_sort | Romero, Gabriel E |
collection | PubMed |
description | Activity in each brain region is shaped by the convergence of ascending and descending axonal pathways, and the balance and characteristics of these determine the neural output. The medial olivocochlear (MOC) efferent system is part of a reflex arc that critically controls auditory sensitivity. Multiple central pathways contact MOC neurons, raising the question of how a reflex arc could be engaged by diverse inputs. We examined functional properties of synapses onto brainstem MOC neurons from ascending (ventral cochlear nucleus, VCN) and descending (inferior colliculus, IC) sources in mice using an optogenetic approach. We found that these pathways exhibited opposing forms of short-term plasticity, with the VCN input showing depression and the IC input showing marked facilitation. By using a conductance-clamp approach, we found that combinations of facilitating and depressing inputs enabled firing of MOC neurons over a surprisingly wide dynamic range, suggesting an essential role for descending signaling to a brainstem nucleus. |
format | Online Article Text |
id | pubmed-8321555 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-83215552021-07-30 Distinct forms of synaptic plasticity during ascending vs descending control of medial olivocochlear efferent neurons Romero, Gabriel E Trussell, Laurence O eLife Neuroscience Activity in each brain region is shaped by the convergence of ascending and descending axonal pathways, and the balance and characteristics of these determine the neural output. The medial olivocochlear (MOC) efferent system is part of a reflex arc that critically controls auditory sensitivity. Multiple central pathways contact MOC neurons, raising the question of how a reflex arc could be engaged by diverse inputs. We examined functional properties of synapses onto brainstem MOC neurons from ascending (ventral cochlear nucleus, VCN) and descending (inferior colliculus, IC) sources in mice using an optogenetic approach. We found that these pathways exhibited opposing forms of short-term plasticity, with the VCN input showing depression and the IC input showing marked facilitation. By using a conductance-clamp approach, we found that combinations of facilitating and depressing inputs enabled firing of MOC neurons over a surprisingly wide dynamic range, suggesting an essential role for descending signaling to a brainstem nucleus. eLife Sciences Publications, Ltd 2021-07-12 /pmc/articles/PMC8321555/ /pubmed/34250904 http://dx.doi.org/10.7554/eLife.66396 Text en © 2021, Romero and Trussell https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Romero, Gabriel E Trussell, Laurence O Distinct forms of synaptic plasticity during ascending vs descending control of medial olivocochlear efferent neurons |
title | Distinct forms of synaptic plasticity during ascending vs descending control of medial olivocochlear efferent neurons |
title_full | Distinct forms of synaptic plasticity during ascending vs descending control of medial olivocochlear efferent neurons |
title_fullStr | Distinct forms of synaptic plasticity during ascending vs descending control of medial olivocochlear efferent neurons |
title_full_unstemmed | Distinct forms of synaptic plasticity during ascending vs descending control of medial olivocochlear efferent neurons |
title_short | Distinct forms of synaptic plasticity during ascending vs descending control of medial olivocochlear efferent neurons |
title_sort | distinct forms of synaptic plasticity during ascending vs descending control of medial olivocochlear efferent neurons |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321555/ https://www.ncbi.nlm.nih.gov/pubmed/34250904 http://dx.doi.org/10.7554/eLife.66396 |
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