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Evaluation of the Amounts of Sennosides A and B in Rhubarb-containing Kampo Medicines to Create a Ranking of Kampo Medicines for Appropriate Selection of Laxatives
OBJECTIVES: To evaluate 20 Kampo medicines, which comprised 6 formulas, Otsujito, Junchoto, Tokakujokito, Bofutsushosan, Mashiningan, and Keishikashakuyakudaioto, from 7 brands, to create a ranking of Kampo medicines for appropriate selection of laxatives. METHODS: The amounts of sennosides A and B,...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japan Society of Coloproctology
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321582/ https://www.ncbi.nlm.nih.gov/pubmed/34395934 http://dx.doi.org/10.23922/jarc.2020-102 |
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author | Ogawa, Kakuyou Tashima, Ai Okazaki, Keisuke Morinaga, Osamu |
author_facet | Ogawa, Kakuyou Tashima, Ai Okazaki, Keisuke Morinaga, Osamu |
author_sort | Ogawa, Kakuyou |
collection | PubMed |
description | OBJECTIVES: To evaluate 20 Kampo medicines, which comprised 6 formulas, Otsujito, Junchoto, Tokakujokito, Bofutsushosan, Mashiningan, and Keishikashakuyakudaioto, from 7 brands, to create a ranking of Kampo medicines for appropriate selection of laxatives. METHODS: The amounts of sennosides A and B, the important components showing laxative effects contained in Kampo medicines, were analysed using High Performance Liquid Chromatography. RESULTS: We found that the amounts of sennosides A and B were different among brands, even when they had the same formula. Furthermore, the amounts of sennosides differed when the same amounts of rhubarb were used. CONCLUSIONS: These results suggest that the differences in amounts of sennosides are caused by the quality of the rhubarb used. Kampo medicines containing laxatives other than rhubarb, including disodium sulphate and hemp seed, had synergistic laxative effects. Thus, in the future, it may be possible to adjust laxative potency of Kampo medicines through further clinical tests. |
format | Online Article Text |
id | pubmed-8321582 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Japan Society of Coloproctology |
record_format | MEDLINE/PubMed |
spelling | pubmed-83215822021-08-12 Evaluation of the Amounts of Sennosides A and B in Rhubarb-containing Kampo Medicines to Create a Ranking of Kampo Medicines for Appropriate Selection of Laxatives Ogawa, Kakuyou Tashima, Ai Okazaki, Keisuke Morinaga, Osamu J Anus Rectum Colon Original Research Article OBJECTIVES: To evaluate 20 Kampo medicines, which comprised 6 formulas, Otsujito, Junchoto, Tokakujokito, Bofutsushosan, Mashiningan, and Keishikashakuyakudaioto, from 7 brands, to create a ranking of Kampo medicines for appropriate selection of laxatives. METHODS: The amounts of sennosides A and B, the important components showing laxative effects contained in Kampo medicines, were analysed using High Performance Liquid Chromatography. RESULTS: We found that the amounts of sennosides A and B were different among brands, even when they had the same formula. Furthermore, the amounts of sennosides differed when the same amounts of rhubarb were used. CONCLUSIONS: These results suggest that the differences in amounts of sennosides are caused by the quality of the rhubarb used. Kampo medicines containing laxatives other than rhubarb, including disodium sulphate and hemp seed, had synergistic laxative effects. Thus, in the future, it may be possible to adjust laxative potency of Kampo medicines through further clinical tests. The Japan Society of Coloproctology 2021-07-29 /pmc/articles/PMC8321582/ /pubmed/34395934 http://dx.doi.org/10.23922/jarc.2020-102 Text en Copyright © 2021 by The Japan Society of Coloproctology https://creativecommons.org/licenses/by-nc-nd/4.0/Journal of the Anus, Rectum and Colon is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Research Article Ogawa, Kakuyou Tashima, Ai Okazaki, Keisuke Morinaga, Osamu Evaluation of the Amounts of Sennosides A and B in Rhubarb-containing Kampo Medicines to Create a Ranking of Kampo Medicines for Appropriate Selection of Laxatives |
title | Evaluation of the Amounts of Sennosides A and B in Rhubarb-containing Kampo Medicines to Create a Ranking of Kampo Medicines for Appropriate Selection of Laxatives |
title_full | Evaluation of the Amounts of Sennosides A and B in Rhubarb-containing Kampo Medicines to Create a Ranking of Kampo Medicines for Appropriate Selection of Laxatives |
title_fullStr | Evaluation of the Amounts of Sennosides A and B in Rhubarb-containing Kampo Medicines to Create a Ranking of Kampo Medicines for Appropriate Selection of Laxatives |
title_full_unstemmed | Evaluation of the Amounts of Sennosides A and B in Rhubarb-containing Kampo Medicines to Create a Ranking of Kampo Medicines for Appropriate Selection of Laxatives |
title_short | Evaluation of the Amounts of Sennosides A and B in Rhubarb-containing Kampo Medicines to Create a Ranking of Kampo Medicines for Appropriate Selection of Laxatives |
title_sort | evaluation of the amounts of sennosides a and b in rhubarb-containing kampo medicines to create a ranking of kampo medicines for appropriate selection of laxatives |
topic | Original Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321582/ https://www.ncbi.nlm.nih.gov/pubmed/34395934 http://dx.doi.org/10.23922/jarc.2020-102 |
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