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Tympanic Membrane Retractions in patients with Williams Syndrome: A Controlled Study

Introduction  The role of elastin in tympanic retractions and chronic otitis media is not well established. Williams Syndrome (WS), a pathology related to a mutation in the elastin gene, could generate tympanic retractions. Objective  To compare the prevalence of tympanic retractions among patients...

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Detalles Bibliográficos
Autores principales: Oliveira, Marcelo Wierzynski, Lavinsky, Joel, Valerio, Marcel Machado, Felix, Temis Maria, Lavinsky, Luiz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Thieme Revinter Publicações Ltda. 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321626/
https://www.ncbi.nlm.nih.gov/pubmed/34377182
http://dx.doi.org/10.1055/s-0040-1715151
Descripción
Sumario:Introduction  The role of elastin in tympanic retractions and chronic otitis media is not well established. Williams Syndrome (WS), a pathology related to a mutation in the elastin gene, could generate tympanic retractions. Objective  To compare the prevalence of tympanic retractions among patients with WS and controls. Methods  WS patients ( n  = 43 ears) and controls ( n  = 130 ears) were evaluated by digital otoscopic examination and the degree of tympanic membrane retraction was classified by 2 blinded experienced otolaryngologists. Results  The agreement rate between the evaluators was 71.1% for pars tensa and 65% for pars flaccida retraction ( p  < 0.001). The pars tensa and pars flaccida retractions are present in patients with WS after an adjusted residue of respectively - 2.8 and - 2.6 ( p  = 0.011 and p  = 0.022) compared with controls. Conclusions  Tympanic membrane retractions are not more common in the WS group when compared with controls.