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Vertiginous Episodes in Menière Disease following Transmyringeal Ventilation Tube Insertion: A Systematic Review on the Current State of Evidence

Introduction  Menière disease (MD) is a disorder characterized by episodes of vertigo, sensorineural hearing loss, tinnitus and aural fullness. Objectives  To assess the effect of ventilation tube insertion (VTI) on vertiginous episodes in patients (≥ 18 years old) with MD. Data Synthesis  A systema...

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Autores principales: Grønlund, Casper, Devantier, Louise, Callesen, Henriette Edemann, Hougaard, Dan Dupont, Händel, Mina Nicole, Schmidt, Jesper Hvass, Guldfred, Frank Liviu-Adelin, Djurhuus, Bjarki Ditlev
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Thieme Revinter Publicações Ltda. 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321650/
https://www.ncbi.nlm.nih.gov/pubmed/34377186
http://dx.doi.org/10.1055/s-0040-1714131
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author Grønlund, Casper
Devantier, Louise
Callesen, Henriette Edemann
Hougaard, Dan Dupont
Händel, Mina Nicole
Schmidt, Jesper Hvass
Guldfred, Frank Liviu-Adelin
Djurhuus, Bjarki Ditlev
author_facet Grønlund, Casper
Devantier, Louise
Callesen, Henriette Edemann
Hougaard, Dan Dupont
Händel, Mina Nicole
Schmidt, Jesper Hvass
Guldfred, Frank Liviu-Adelin
Djurhuus, Bjarki Ditlev
author_sort Grønlund, Casper
collection PubMed
description Introduction  Menière disease (MD) is a disorder characterized by episodes of vertigo, sensorineural hearing loss, tinnitus and aural fullness. Objectives  To assess the effect of ventilation tube insertion (VTI) on vertiginous episodes in patients (≥ 18 years old) with MD. Data Synthesis  A systematic literature search on randomized clinical trials (RCTs), nonrandomized trials and other systematic reviews was performed. The Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) approach was used to assess the overall certainty of evidence. Two RCTs and four nonrandomized studies were identified. Data extraction was only possible for one RCT. Results showed that the number of patients with no vertigo attacks significantly increased following active treatment (relative risk 1.52; [95% confidence interval: 1.19–1.94]). The quality of evidence was rated as low. None of the nonrandomized trials included a proper control group, which hindered data extraction and quality assessment. Conclusion  There are currently no RCTs that specifically assess the efficacy of VTI in patients with MD. Current limited data suggest a considerable positive effect on the number of vertiginous episodes in patients with MD. However, due to poor evidence, a fluctuating course and a substantial placebo-effect associated with MD-treatment, no solid conclusion(s) regarding the efficacy of VTI can be made. There is a need for high-quality RCTs.
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spelling pubmed-83216502021-08-09 Vertiginous Episodes in Menière Disease following Transmyringeal Ventilation Tube Insertion: A Systematic Review on the Current State of Evidence Grønlund, Casper Devantier, Louise Callesen, Henriette Edemann Hougaard, Dan Dupont Händel, Mina Nicole Schmidt, Jesper Hvass Guldfred, Frank Liviu-Adelin Djurhuus, Bjarki Ditlev Int Arch Otorhinolaryngol Introduction  Menière disease (MD) is a disorder characterized by episodes of vertigo, sensorineural hearing loss, tinnitus and aural fullness. Objectives  To assess the effect of ventilation tube insertion (VTI) on vertiginous episodes in patients (≥ 18 years old) with MD. Data Synthesis  A systematic literature search on randomized clinical trials (RCTs), nonrandomized trials and other systematic reviews was performed. The Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) approach was used to assess the overall certainty of evidence. Two RCTs and four nonrandomized studies were identified. Data extraction was only possible for one RCT. Results showed that the number of patients with no vertigo attacks significantly increased following active treatment (relative risk 1.52; [95% confidence interval: 1.19–1.94]). The quality of evidence was rated as low. None of the nonrandomized trials included a proper control group, which hindered data extraction and quality assessment. Conclusion  There are currently no RCTs that specifically assess the efficacy of VTI in patients with MD. Current limited data suggest a considerable positive effect on the number of vertiginous episodes in patients with MD. However, due to poor evidence, a fluctuating course and a substantial placebo-effect associated with MD-treatment, no solid conclusion(s) regarding the efficacy of VTI can be made. There is a need for high-quality RCTs. Thieme Revinter Publicações Ltda. 2021-07 2020-09-30 /pmc/articles/PMC8321650/ /pubmed/34377186 http://dx.doi.org/10.1055/s-0040-1714131 Text en Fundação Otorrinolaringologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Grønlund, Casper
Devantier, Louise
Callesen, Henriette Edemann
Hougaard, Dan Dupont
Händel, Mina Nicole
Schmidt, Jesper Hvass
Guldfred, Frank Liviu-Adelin
Djurhuus, Bjarki Ditlev
Vertiginous Episodes in Menière Disease following Transmyringeal Ventilation Tube Insertion: A Systematic Review on the Current State of Evidence
title Vertiginous Episodes in Menière Disease following Transmyringeal Ventilation Tube Insertion: A Systematic Review on the Current State of Evidence
title_full Vertiginous Episodes in Menière Disease following Transmyringeal Ventilation Tube Insertion: A Systematic Review on the Current State of Evidence
title_fullStr Vertiginous Episodes in Menière Disease following Transmyringeal Ventilation Tube Insertion: A Systematic Review on the Current State of Evidence
title_full_unstemmed Vertiginous Episodes in Menière Disease following Transmyringeal Ventilation Tube Insertion: A Systematic Review on the Current State of Evidence
title_short Vertiginous Episodes in Menière Disease following Transmyringeal Ventilation Tube Insertion: A Systematic Review on the Current State of Evidence
title_sort vertiginous episodes in menière disease following transmyringeal ventilation tube insertion: a systematic review on the current state of evidence
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321650/
https://www.ncbi.nlm.nih.gov/pubmed/34377186
http://dx.doi.org/10.1055/s-0040-1714131
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