Deletion of a pseudogene within a fragile site triggers the oncogenic expression of the mitotic CCSER1 gene

The oncogenic role of common fragile sites (CFS), focal and pervasive gaps in the cancer genome arising from replicative stress, remains controversial. Exploiting the TCGA dataset, we found that in most CFS the genes residing within the associated focal deletions are down-regulated, including protei...

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Detalles Bibliográficos
Autores principales: Santoliquido, Benedetta M, Frenquelli, Michela, Contadini, Claudia, Bestetti, Stefano, Gaviraghi, Marco, Barbieri, Elisa, De Antoni, Anna, Albarello, Luca, Amabile, Angelo, Gardini, Alessandro, Lombardo, Angelo, Doglioni, Claudio, Provero, Paolo, Soddu, Silvia, Cittaro, Davide, Tonon, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321653/
https://www.ncbi.nlm.nih.gov/pubmed/34187875
http://dx.doi.org/10.26508/lsa.202101019

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