Increased exosome secretion in neurons aging in vitro by NPC1-mediated endosomal cholesterol buildup

As neurons age, they show a decrease in their ability to degrade proteins and membranes. Because undegraded material is a source of toxic products, defects in degradation are associated with reduced cell function and survival. However, there are very few dead neurons in the aging brain, suggesting t...

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Detalles Bibliográficos
Autores principales: Guix, Francesc X, Capitán, Ana Marrero, Casadomé-Perales, Álvaro, Palomares-Pérez, Irene, López del Castillo, Inés, Miguel, Verónica, Goedeke, Leigh, Martín, Mauricio G, Lamas, Santiago, Peinado, Héctor, Fernández-Hernando, Carlos, Dotti, Carlos G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321659/
https://www.ncbi.nlm.nih.gov/pubmed/34183444
http://dx.doi.org/10.26508/lsa.202101055

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321659/
https://www.ncbi.nlm.nih.gov/pubmed/34183444
http://dx.doi.org/10.26508/lsa.202101055

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