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Increased exosome secretion in neurons aging in vitro by NPC1-mediated endosomal cholesterol buildup
As neurons age, they show a decrease in their ability to degrade proteins and membranes. Because undegraded material is a source of toxic products, defects in degradation are associated with reduced cell function and survival. However, there are very few dead neurons in the aging brain, suggesting t...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Life Science Alliance LLC
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321659/ https://www.ncbi.nlm.nih.gov/pubmed/34183444 http://dx.doi.org/10.26508/lsa.202101055 |