Cargando…

Negative correlation of single-cell PAX3:FOXO1 expression with tumorigenicity in rhabdomyosarcoma

Rhabdomyosarcomas (RMS) are phenotypically and functionally heterogeneous. Both primary human RMS cultures and low-passage Myf6Cre,Pax3:Foxo1,p53 mouse RMS cell lines, which express the fusion oncoprotein Pax3:Foxo1 and lack the tumor suppressor Tp53 (Myf6Cre,Pax3:Foxo1,p53), exhibit marked heteroge...

Descripción completa

Detalles Bibliográficos
Autores principales:	Regina, Carla, Hamed, Ebrahem, Andrieux, Geoffroy, Angenendt, Sina, Schneider, Michaela, Ku, Manching, Follo, Marie, Wachtel, Marco, Ke, Eugene, Kikuchi, Ken, Henssen, Anton G, Schäfer, Beat W, Boerries, Melanie, Wagers, Amy J, Keller, Charles, Hettmer, Simone
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Life Science Alliance LLC 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321661/ https://www.ncbi.nlm.nih.gov/pubmed/34187933 http://dx.doi.org/10.26508/lsa.202001002

Ejemplares similares

Genomic and Epigenetic Changes Drive Aberrant Skeletal Muscle Differentiation in Rhabdomyosarcoma
por: Pomella, Silvia, et al.
Publicado: (2023)

Identification of target genes of PAX3-FOXO1 in alveolar rhabdomyosarcoma
por: AHN, EUN HYUN, et al.
Publicado: (2013)

FOXF1 is required for the oncogenic properties of PAX3-FOXO1 in rhabdomyosarcoma.
por: Milewski, David, et al.
Publicado: (2021)

Alveolar rhabdomyosarcoma – The molecular drivers of PAX3/7-FOXO1-induced tumorigenesis
por: Marshall, Amy D, et al.
Publicado: (2012)

PAX3-FOXO1 dictates myogenic reprogramming and rhabdomyosarcoma identity in endothelial progenitors
por: Searcy, Madeline B., et al.
Publicado: (2023)

The PAX3-FOXO1 Fusion Protein Present in Rhabdomyosarcoma Interferes with Normal FOXO Activity and the TGF-β Pathway
por: Schmitt-Ney, Michel, et al.
Publicado: (2015)

Therapeutic Approaches Targeting PAX3-FOXO1 and Its Regulatory and Transcriptional Pathways in Rhabdomyosarcoma
por: Nguyen, Thanh Hung, et al.
Publicado: (2018)

MS-275 (Entinostat) Promotes Radio-Sensitivity in PAX3-FOXO1 Rhabdomyosarcoma Cells
por: Cassandri, Matteo, et al.
Publicado: (2021)

PPP2R1A regulated by PAX3/FOXO1 fusion contributes to the acquisition of aggressive behavior in PAX3/FOXO1-positive alveolar rhabdomyosarcoma
por: Akaike, Keisuke, et al.
Publicado: (2018)

Growth inhibition associated with disruption of the actin cytoskeleton by Latrunculin A in rhabdomyosarcoma cells
por: Würtemberger, Julia, et al.
Publicado: (2020)

Fenretinide Acts as Potent Radiosensitizer for Treatment of Rhabdomyosarcoma Cells
por: Brack, Eva, et al.
Publicado: (2021)

PAX3-FOXO1 transgenic zebrafish models identify HES3 as a mediator of rhabdomyosarcoma tumorigenesis
por: Kendall, Genevieve C, et al.
Publicado: (2018)

Regulatory landscape fusion in rhabdomyosarcoma through interactions between the PAX3 promoter and FOXO1 regulatory elements
por: Vicente-García, Cristina, et al.
Publicado: (2017)

Reduced B7-H3 expression by PAX3-FOXO1 knockdown inhibits cellular motility and promotes myogenic differentiation in alveolar rhabdomyosarcoma
por: Kanayama, Takuyo, et al.
Publicado: (2021)

Cyclin-Dependent Kinase 4 Phosphorylates and Positively Regulates PAX3-FOXO1 in Human Alveolar Rhabdomyosarcoma Cells
por: Liu, Lingling, et al.
Publicado: (2013)

Inhibiting phosphorylation of the oncogenic PAX3-FOXO1 reduces alveolar rhabdomyosarcoma phenotypes identifying novel therapy options
por: Loupe, J M, et al.
Publicado: (2015)

OLIG2 is a novel immunohistochemical marker associated with the presence of PAX3/7-FOXO1 translocation in rhabdomyosarcomas
por: Kaleta, Magdalena, et al.
Publicado: (2019)

Mutant myogenin promoter-controlled oncolytic adenovirus selectively kills PAX3-FOXO1-positive rhabdomyosarcoma cells
por: Yoshida, Hideki, et al.
Publicado: (2020)

Divergent transcriptional and transforming properties of PAX3-FOXO1 and PAX7-FOXO1 paralogs
por: Manceau, Line, et al.
Publicado: (2022)

JARID2 is a direct target of the PAX3-FOXO1 fusion protein and inhibits myogenic differentiation of rhabdomyosarcoma cells
por: Walters, Zoë S, et al.
Publicado: (2013)

Cell-Cycle Dependent Expression of a Translocation-Mediated Fusion Oncogene Mediates Checkpoint Adaptation in Rhabdomyosarcoma
por: Kikuchi, Ken, et al.
Publicado: (2014)

Modeling of the Human Alveolar Rhabdomyosarcoma Pax3-Foxo1 Chromosome Translocation in Mouse Myoblasts Using CRISPR-Cas9 Nuclease
por: Lagutina, Irina V., et al.
Publicado: (2015)

Identify potential driver genes for PAX-FOXO1 fusion-negative rhabdomyosarcoma through frequent gene co-expression network mining
por: Zhan, Xiaohui, et al.
Publicado: (2023)

PAX3-FOXO1 drives miR-486-5p and represses miR-221 contributing to pathogenesis of alveolar rhabdomyosarcoma
por: Hanna, Jason A., et al.
Publicado: (2018)

Synthetic MIR143-3p Suppresses Cell Growth in Rhabdomyosarcoma Cells by Interrupting RAS Pathways Including PAX3–FOXO1
por: Sugito, Nobuhiko, et al.
Publicado: (2020)

The proprotein convertase furin is required to maintain viability of alveolar rhabdomyosarcoma cells
por: Jaaks, Patricia, et al.
Publicado: (2016)

c-Myb regulates tumorigenic potential of embryonal rhabdomyosarcoma cells
por: Kaspar, Petr, et al.
Publicado: (2019)

Alveolar rhabdomyosarcoma: morphoproteomics and personalized tumor graft testing further define the biology of PAX3-FKHR(FOXO1) subtype and provide targeted therapeutic options
por: Brown, Robert E., et al.
Publicado: (2016)

The PAX-FOXO1s trigger fast trans-differentiation of chick embryonic neural cells into alveolar rhabdomyosarcoma with tissue invasive properties limited by S phase entry inhibition
por: Gonzalez Curto, Gloria, et al.
Publicado: (2020)

Genetic Characterization, Current Model Systems and Prognostic Stratification in PAX Fusion-Negative vs. PAX Fusion-Positive Rhabdomyosarcoma
por: Dehner, Carina A., et al.
Publicado: (2021)

Lack of Electron Acceptors Contributes to Redox Stress and Growth Arrest in Asparagine-Starved Sarcoma Cells
por: Bauer, Christoph, et al.
Publicado: (2021)

A role for PAX8 in the tumorigenic phenotype of ovarian cancer cells
por: Di Palma, Tina, et al.
Publicado: (2014)

KDM3A/Ets1 epigenetic axis contributes to PAX3/FOXO1‐driven and independent disease‐promoting gene expression in fusion‐positive Rhabdomyosarcoma
por: Sobral, Lays M., et al.
Publicado: (2020)

Current and Future Treatment Strategies for Rhabdomyosarcoma
por: Chen, Celine, et al.
Publicado: (2019)

PAX7 expression in embryonal rhabdomyosarcoma suggests an origin in muscle satellite cells
por: Tiffin, N, et al.
Publicado: (2003)

Alteration of Proteotranscriptomic Landscape Reveals the Transcriptional Regulatory Circuits Controlling Key-Signaling Pathways and Metabolic Reprogramming During Tumor Evolution
por: Andrieux, Geoffroy, et al.
Publicado: (2020)

Single-cell profiling of alveolar rhabdomyosarcoma reveals RAS pathway inhibitors as cell-fate hijackers with therapeutic relevance
por: Danielli, Sara G., et al.
Publicado: (2023)

A combinatorial drug screen in PDX-derived primary rhabdomyosarcoma cells identifies the NOXA - BCL-XL/MCL-1 balance as target for re-sensitization to first-line therapy in recurrent tumors
por: Manzella, Gabriele, et al.
Publicado: (2021)

The Proprotein Convertase Furin Contributes to Rhabdomyosarcoma Malignancy by Promoting Vascularization, Migration and Invasion
por: Jaaks, Patricia, et al.
Publicado: (2016)

ACTA1 is inhibited by PAX3-FOXO1 through RhoA-MKL1-SRF signaling pathway and impairs cell proliferation, migration and tumor growth in Alveolar Rhabdomyosarcoma
por: Hu, Qiande, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_fgbkci917v33i1bcd7jp7ter36