Exosome-mediated delivery of CRISPR/Cas9 for targeting of oncogenic Kras(G12D) in pancreatic cancer

CRISPR/Cas9 is a promising technology for gene editing. To date, intracellular delivery vehicles for CRISPR/Cas9 are limited by issues of immunogenicity, restricted packaging capacity, and low tolerance. Here, we report an alternative, nonviral delivery system for CRISPR/Cas9 based on engineered exo...

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Detalles Bibliográficos
Autores principales: McAndrews, Kathleen M, Xiao, Fei, Chronopoulos, Antonios, LeBleu, Valerie S, Kugeratski, Fernanda G, Kalluri, Raghu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321670/
https://www.ncbi.nlm.nih.gov/pubmed/34282051
http://dx.doi.org/10.26508/lsa.202000875

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321670/
https://www.ncbi.nlm.nih.gov/pubmed/34282051
http://dx.doi.org/10.26508/lsa.202000875

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