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Role of Extracellular Vesicles in Compromising Cellular Resilience to Environmental Stressors

Extracellular vesicles (EVs), like exosomes, are nanosized membrane-enveloped vesicles containing different bioactive cargo, such as proteins, lipids, mRNA, miRNA, and other small regulatory RNAs. Cell-derived EVs, including EVs originating from stem cells, may capture components from damaged cells...

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Detalles Bibliográficos
Autores principales: Alharbi, Mona G., Lee, Seok Hee, Abdelazim, Aaser M., Saadeldin, Islam M., Abomughaid, Mosleh M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321721/
https://www.ncbi.nlm.nih.gov/pubmed/34337063
http://dx.doi.org/10.1155/2021/9912281
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author Alharbi, Mona G.
Lee, Seok Hee
Abdelazim, Aaser M.
Saadeldin, Islam M.
Abomughaid, Mosleh M.
author_facet Alharbi, Mona G.
Lee, Seok Hee
Abdelazim, Aaser M.
Saadeldin, Islam M.
Abomughaid, Mosleh M.
author_sort Alharbi, Mona G.
collection PubMed
description Extracellular vesicles (EVs), like exosomes, are nanosized membrane-enveloped vesicles containing different bioactive cargo, such as proteins, lipids, mRNA, miRNA, and other small regulatory RNAs. Cell-derived EVs, including EVs originating from stem cells, may capture components from damaged cells or cells impacted by therapeutic treatments. Interestingly, EVs derived from stem cells can be preconditioned to produce and secrete EVs with different therapeutic properties, particularly with respect to heat-shock proteins and other molecular cargo contents. This behavior is consistent with stem cells that also respond differently to various microenvironments. Heat-shock proteins play roles in cellular protection and mediate cellular resistance to radiotherapy, chemotherapy, and heat shock. This review highlights the possible roles EVs play in mediating cellular plasticity and survival when exposed to different physical and chemical stressors, with a special focus on the respiratory distress due to the air pollution.
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spelling pubmed-83217212021-07-31 Role of Extracellular Vesicles in Compromising Cellular Resilience to Environmental Stressors Alharbi, Mona G. Lee, Seok Hee Abdelazim, Aaser M. Saadeldin, Islam M. Abomughaid, Mosleh M. Biomed Res Int Review Article Extracellular vesicles (EVs), like exosomes, are nanosized membrane-enveloped vesicles containing different bioactive cargo, such as proteins, lipids, mRNA, miRNA, and other small regulatory RNAs. Cell-derived EVs, including EVs originating from stem cells, may capture components from damaged cells or cells impacted by therapeutic treatments. Interestingly, EVs derived from stem cells can be preconditioned to produce and secrete EVs with different therapeutic properties, particularly with respect to heat-shock proteins and other molecular cargo contents. This behavior is consistent with stem cells that also respond differently to various microenvironments. Heat-shock proteins play roles in cellular protection and mediate cellular resistance to radiotherapy, chemotherapy, and heat shock. This review highlights the possible roles EVs play in mediating cellular plasticity and survival when exposed to different physical and chemical stressors, with a special focus on the respiratory distress due to the air pollution. Hindawi 2021-07-20 /pmc/articles/PMC8321721/ /pubmed/34337063 http://dx.doi.org/10.1155/2021/9912281 Text en Copyright © 2021 Mona G. Alharbi et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Alharbi, Mona G.
Lee, Seok Hee
Abdelazim, Aaser M.
Saadeldin, Islam M.
Abomughaid, Mosleh M.
Role of Extracellular Vesicles in Compromising Cellular Resilience to Environmental Stressors
title Role of Extracellular Vesicles in Compromising Cellular Resilience to Environmental Stressors
title_full Role of Extracellular Vesicles in Compromising Cellular Resilience to Environmental Stressors
title_fullStr Role of Extracellular Vesicles in Compromising Cellular Resilience to Environmental Stressors
title_full_unstemmed Role of Extracellular Vesicles in Compromising Cellular Resilience to Environmental Stressors
title_short Role of Extracellular Vesicles in Compromising Cellular Resilience to Environmental Stressors
title_sort role of extracellular vesicles in compromising cellular resilience to environmental stressors
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321721/
https://www.ncbi.nlm.nih.gov/pubmed/34337063
http://dx.doi.org/10.1155/2021/9912281
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