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Síndrome de encefalopatía posterior reversible en pacientes críticos COVID-19: reporte de 2 casos
Posterior reversible encephalopathy syndrome is an acute neurological disorder characterized by variable symptoms and radiological images characteristic of vasogenic parietal-occipital edema. It is associated with clinical conditions such as high blood pressure, infection/sepsis, or cytotoxic/immuno...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor. Published by Elsevier España, S.L.U.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321770/ https://www.ncbi.nlm.nih.gov/pubmed/34345055 http://dx.doi.org/10.1016/j.redar.2021.05.022 |
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author | Tortajada Soler, J.J. Tauler Redondo, M.P. Garví López, M. Lozano Serrano, M.B. López-Torres López, J. Sánchez López, M.L. |
author_facet | Tortajada Soler, J.J. Tauler Redondo, M.P. Garví López, M. Lozano Serrano, M.B. López-Torres López, J. Sánchez López, M.L. |
author_sort | Tortajada Soler, J.J. |
collection | PubMed |
description | Posterior reversible encephalopathy syndrome is an acute neurological disorder characterized by variable symptoms and radiological images characteristic of vasogenic parietal-occipital edema. It is associated with clinical conditions such as high blood pressure, infection/sepsis, or cytotoxic/immunosuppressive drugs, among others. It is characterized pathophysiologically by endothelial damage with breakdown of blood-brain barrier, cerebral hypoperfusion, and vasogenic edema. The cases are presented on 2 critical COVID-19 patients who were admitted to pneumonia requiring mechanical ventilation and who, after removing sedation, developed acute and reversible neurological symptoms consisting of epilepsy and encephalopathy, associated with hyperintense subcortical lesions on brain magnetic resonance imaging compatible with posterior reversible encephalopathy syndrome. SARS-CoV-2 coronavirus would activate an inflammatory response that would damage brain endothelium. It could be triggered by cytokine release, as well as by direct viral injury, given that endothelium expresses ACE2 receptors. It could explain the possible association between posterior reversible encephalopathy syndrome and COVID-19. |
format | Online Article Text |
id | pubmed-8321770 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor. Published by Elsevier España, S.L.U. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83217702021-07-30 Síndrome de encefalopatía posterior reversible en pacientes críticos COVID-19: reporte de 2 casos Tortajada Soler, J.J. Tauler Redondo, M.P. Garví López, M. Lozano Serrano, M.B. López-Torres López, J. Sánchez López, M.L. Rev Esp Anestesiol Reanim Caso Clínico Posterior reversible encephalopathy syndrome is an acute neurological disorder characterized by variable symptoms and radiological images characteristic of vasogenic parietal-occipital edema. It is associated with clinical conditions such as high blood pressure, infection/sepsis, or cytotoxic/immunosuppressive drugs, among others. It is characterized pathophysiologically by endothelial damage with breakdown of blood-brain barrier, cerebral hypoperfusion, and vasogenic edema. The cases are presented on 2 critical COVID-19 patients who were admitted to pneumonia requiring mechanical ventilation and who, after removing sedation, developed acute and reversible neurological symptoms consisting of epilepsy and encephalopathy, associated with hyperintense subcortical lesions on brain magnetic resonance imaging compatible with posterior reversible encephalopathy syndrome. SARS-CoV-2 coronavirus would activate an inflammatory response that would damage brain endothelium. It could be triggered by cytokine release, as well as by direct viral injury, given that endothelium expresses ACE2 receptors. It could explain the possible association between posterior reversible encephalopathy syndrome and COVID-19. Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor. Published by Elsevier España, S.L.U. 2023-01 2021-07-30 /pmc/articles/PMC8321770/ /pubmed/34345055 http://dx.doi.org/10.1016/j.redar.2021.05.022 Text en © 2021 Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor. Published by Elsevier España, S.L.U. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Caso Clínico Tortajada Soler, J.J. Tauler Redondo, M.P. Garví López, M. Lozano Serrano, M.B. López-Torres López, J. Sánchez López, M.L. Síndrome de encefalopatía posterior reversible en pacientes críticos COVID-19: reporte de 2 casos |
title | Síndrome de encefalopatía posterior reversible en pacientes críticos COVID-19: reporte de 2 casos |
title_full | Síndrome de encefalopatía posterior reversible en pacientes críticos COVID-19: reporte de 2 casos |
title_fullStr | Síndrome de encefalopatía posterior reversible en pacientes críticos COVID-19: reporte de 2 casos |
title_full_unstemmed | Síndrome de encefalopatía posterior reversible en pacientes críticos COVID-19: reporte de 2 casos |
title_short | Síndrome de encefalopatía posterior reversible en pacientes críticos COVID-19: reporte de 2 casos |
title_sort | síndrome de encefalopatía posterior reversible en pacientes críticos covid-19: reporte de 2 casos |
topic | Caso Clínico |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321770/ https://www.ncbi.nlm.nih.gov/pubmed/34345055 http://dx.doi.org/10.1016/j.redar.2021.05.022 |
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