Lactate and glutamine support NADPH generation in cancer cells under glucose deprived conditions

Although glucose, through pentose phosphate pathway (PPP), is the main source to generate NADPH, solid tumors are often deprived of glucose, hence alternative metabolic pathways to maintain NADPH homeostasis in cancer cells are required. Here, we report that lactate and glutamine support NADPH produ...

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Detalles Bibliográficos
Autores principales: Ying, Minfeng, You, Duo, Zhu, Xiaobing, Cai, Limeng, Zeng, Siying, Hu, Xun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321918/
https://www.ncbi.nlm.nih.gov/pubmed/34293554
http://dx.doi.org/10.1016/j.redox.2021.102065

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